磁性平阳霉素微球治疗海绵状血管瘤的实验研究
[Experimental study of magnetic pingyangmycine-bearing microspheres in the treatment of cavernous hemangioma].
作者信息
Zhang Sheng, Wu Han-jiang, Ling Tian-you
机构信息
Department of Stomatology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
出版信息
Hunan Yi Ke Da Xue Xue Bao. 2003 Feb 28;28(1):23-5.
OBJECTIVE
To investigate the probability and mechanism magnetic pingyangmycine-bearing microspheres(MPMs) in the treatment of cavernous hemangioma.
METHODS
Twenty rabbits were divided into four groups. MPMs, pingyangmycine and magnetic nonpingyangmycine-bearing microspheres were injected into marginal ear veins respectively. All animals were killed after 21 days and histological varations of the veins were observed under the light microscope and transmission electron microscope.
RESULTS
The occlusion of the veins in the group of MPMs with the external magnetic field was more prominent than that in the other groups.
CONCLUSION
MPMs can occlude veins by means of its embolized effect and PYM drug effect. MPMs may be better used in the therapy of cavernous hemangioma.
目的
探讨磁性平阳霉素微球（MPMs）治疗海绵状血管瘤的可能性及机制。
方法
将20只家兔分为4组，分别经耳缘静脉注入MPMs、平阳霉素及磁性非平阳霉素微球。21天后处死所有动物，在光学显微镜和透射电子显微镜下观察静脉的组织学变化。
结果
加外磁场的MPMs组静脉闭塞情况比其他组更显著。
结论
MPMs可通过其栓塞作用及平阳霉素（PYM）药物作用闭塞静脉。MPMs可能更适用于海绵状血管瘤的治疗。
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