Watanabe Kazuo, Hiroki Tadayuki, Koga Nobuhiko
Department of Internal Medicine/Cardiology, Fukuoka University, Chikushi Hospital, Fukuoka, Japan.
Angiology. 2003 Jul-Aug;54(4):433-41. doi: 10.1177/000331970305400407.
The aim of this study was to investigate whether thoracic aorta calcification (TAC) on computed tomography (CT) and coronary risk factors had any correlation with obstructive coronary artery disease (CAD) on angiography. A total of 225 consecutive Japanese patients underwent both thoracic conventional helical CT and coronary angiography. The thoracic aorta was divided into 4 locations according to the aortic anatomy (inner curve of the aortic arch, aortic arch but not on the inner curve, ascending aorta, and thoracic descending aorta). The classified TAC and coronary risk factors were evaluated for the presence or absence of obstructive CAD. TAC was detected in 185 patients; 141 of 225 patients had significant obstructive CAD. All of the 13 patients with no TAC and no coronary risk factors had no CAD. The obstructive CAD rate with 1 thoracic calcified location and with no, 1, or 2 coronary risk factors was 10%, 58%, and 90%, respectively, and each showed a significant difference (p < 0.0001). The combinations of TAC and coronary risk factors with obstructive CAD were 1 or 2 thoracic calcified locations with 3 coronary risk factors, and 3 thoracic calcified locations with more than 2 coronary risk factors. Increasing thoracic calcified locations and increasing coronary risk factors indicated a higher likelihood of CAD.
本研究的目的是调查计算机断层扫描（CT）上的胸主动脉钙化（TAC）和冠状动脉危险因素与血管造影显示的阻塞性冠状动脉疾病（CAD）是否存在任何相关性。共有225例连续的日本患者接受了胸部常规螺旋CT和冠状动脉造影检查。根据主动脉解剖结构将胸主动脉分为4个部位（主动脉弓内曲线、主动脉弓但不在内曲线、升主动脉和胸降主动脉）。对分类后的TAC和冠状动脉危险因素进行评估，以确定是否存在阻塞性CAD。185例患者检测到TAC；225例患者中有141例患有严重的阻塞性CAD。所有13例无TAC且无冠状动脉危险因素的患者均无CAD。有1个胸部钙化部位且无、有1个或2个冠状动脉危险因素的患者，其阻塞性CAD发生率分别为10%、58%和90%，差异均有统计学意义（p<0.0001）。TAC和冠状动脉危险因素与阻塞性CAD的组合为有3个冠状动脉危险因素的1个或2个胸部钙化部位，以及有超过2个冠状动脉危险因素的3个胸部钙化部位。胸部钙化部位增加和冠状动脉危险因素增加表明CAD的可能性更高。
