Bortz Jennifer J
Department of Psychiatry and Psychology, Mayo Clinic, Scottsdale, Ariz, USA.
Mayo Clin Proc. 2003 Jun;78(6):781-7. doi: 10.4065/78.6.781.
Epilepsy is an extremely complex disorder characterized by marked variability in clinical presentation, etiology, diagnostic certainty, and therapeutic options. Neuropsychiatric and cognitive concomitant disorders are equally diverse and complex. Depression and anxiety, for example, may be preexisting conditions, occur only in peri-ictal or ictal states, or persist as constant interictal phenomena; both place additional burden on memory functions, which are further taxed by the effects of recurrent seizures, temporal lobe insult, and antiseizure medications. Such factors present considerable clinical challenges, particularly in outpatient settings. This article provides an overview of major psychiatric features of epilepsy and of issues regarding the nature of memory deficits in this neurologic population. The importance of identifying and treating potentially reversible causes of memory impairment and related forms of cognitive impairment is emphasized.
癫痫是一种极其复杂的疾病，其临床表现、病因、诊断确定性和治疗选择存在显著差异。神经精神和认知伴随疾病同样多样且复杂。例如，抑郁和焦虑可能是既往存在的状况，仅在发作期或发作时出现，或作为持续的发作间期现象持续存在；这两者都会给记忆功能带来额外负担，而反复癫痫发作、颞叶损伤和抗癫痫药物的影响又会进一步加重这种负担。这些因素带来了相当大的临床挑战，尤其是在门诊环境中。本文概述了癫痫的主要精神症状以及该神经疾病群体中记忆缺陷的性质相关问题。文中强调了识别和治疗记忆损害及相关认知损害潜在可逆病因的重要性。
