Chauhan Virander Singh, Bhardwaj Devesh
Malaria Research Group, International Center for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi-110067, India.
Adv Biochem Eng Biotechnol. 2003;84:143-82. doi: 10.1007/3-540-36488-9_5.
There is an urgent need to develop an effective vaccine against malaria--a disease that has approximately 10% of the world population at risk of infection at any given time. The economic burden this disease puts on the medico-social set-up of countries in Sub-Saharan Africa and South East Asia is phenomenal. Increasing drug resistance and failure of vector control strategies have necessitated the search for a suitable vaccine that could be integrated into the extended program of immunization for countries in the endemic regions. Malaria vaccine development has seen a surge of activity in the last decade or so owing largely to the advances made in the fields of genetic engineering and biotechnology. This revolution has brought sweeping changes in the understanding of the biology of the parasite and has helped formulate newer more effective strategies to combat the disease. Latest developments in the field of malaria vaccine development will be discussed in this chapter.
迫切需要研发一种有效的疟疾疫苗——这种疾病在任何时候都使世界约10%的人口面临感染风险。该疾病给撒哈拉以南非洲和东南亚国家的医疗社会体系造成的经济负担是巨大的。耐药性增加以及病媒控制策略的失败使得必须寻找一种合适的疫苗，以便能够纳入流行地区国家的扩大免疫规划。在过去十年左右的时间里，疟疾疫苗的研发活动激增，这主要归功于基因工程和生物技术领域取得的进展。这场革命给对疟原虫生物学的认识带来了彻底变革，并有助于制定更新的、更有效的疾病防治策略。本章将讨论疟疾疫苗研发领域的最新进展。
