Division of Immunology, Queensland Institute of Medical Research, Brisbane, Australia.
Trends Parasitol. 2011 Jun;27(6):274-83. doi: 10.1016/j.pt.2011.01.002. Epub 2011 Apr 30.
In recent years, groundbreaking advances have been made in understanding the biology of and immune mechanisms against the Plasmodium spp. parasite, the causative agent of malaria. Novel features of the Plasmodium life cycle have been unravelled and immune mechanisms, which take place during both infection and immunization, have been dissected. We have undoubtedly enhanced our knowledge, but the question now is how to use this information to manipulate immune responses against Plasmodium and to develop an efficacious malaria vaccine. In this review, we discuss the latest developments in the field and speculate on how immune responses against Plasmodium could be harnessed for rational vaccine design and application.
近年来，人们在了解疟原虫（导致疟疾的寄生虫）的生物学和免疫机制方面取得了突破性进展。疟原虫生命周期的新特征已经被揭示，感染和免疫过程中的免疫机制也已经被剖析。我们无疑已经增强了我们的知识，但现在的问题是如何利用这些信息来操纵针对疟原虫的免疫反应，并开发出有效的疟疾疫苗。在这篇综述中，我们讨论了该领域的最新进展，并推测了如何利用针对疟原虫的免疫反应来进行合理的疫苗设计和应用。
