Sano Mary
Bronx Veterans Medical Research Development, Bronx, NY 10468-3904, USA.
J Clin Psychiatry. 2003;64 Suppl 9:23-8.
Approved treatments for Alzheimer's disease have focused primarily on cholinergic enhancement. New attention, however, is being turned toward preventative treatments such as vitamin E, estrogen, and lipid-lowering agents. Preventative treatments focus on intervening prior to the onset of disease. These treatments are designed to modify the amyloid load. These new approaches require designs that select nonimpaired or minimally impaired populations, using new outcomes with prolonged assessment. The cost of these studies is high, but the potential benefit of delay or prevention of disease is the valuable goal.
已获批的阿尔茨海默病治疗方法主要集中在胆碱能增强方面。然而，新的关注点正转向预防性治疗，如维生素E、雌激素和降脂药物。预防性治疗侧重于在疾病发作前进行干预。这些治疗旨在改变淀粉样蛋白负荷。这些新方法需要采用新的设计，选择未受损或受损最小的人群，并进行长期评估的新结局指标。这些研究成本高昂，但延迟或预防疾病的潜在益处是一个有价值的目标。
