Sandström E, Urassa W, Bakari M, Swai A, Mhalu F, Biberfeld G, Pallangyo K
Karolinska Institute at Söder Hospital, Stockholm, Sweden.
Int J STD AIDS. 2003 Aug;14(8):547-51. doi: 10.1258/095646203767869165.
The relationship between CD4 percent and CD4 count has been reported to be different in industrialized countries compared to sub-Saharan Africa, where often only the former is reliable. CD4 determinations from an open cohort of hotel workers in Dar es Salaam followed between 1990 and 1998 were evaluated. T-lymphocyte determinations were offered once a year to 190 HIV-1 seropositive, 80 seroconverters and 495 sex and age matched HIV-seronegative subjects. After log transformation of the CD4 percent and CD4 counts a good fit to a linear regression curve was found, R(2) 0.697. The CD4 percent corresponding to a CD4 count of 200 cells/mm(3) was found to be 9.8%. CD4 percent determination can be useful to estimate CD4 counts, but needs to be locally standardized. The CD4 percent in Africa corresponding to AIDS defining CD4 counts seems to be lower than in the industrialized world.
据报道，与撒哈拉以南非洲相比，工业化国家中CD4百分比与CD4计数之间的关系有所不同，在撒哈拉以南非洲，通常只有前者是可靠的。对1990年至1998年期间达累斯萨拉姆一个开放队列的酒店工作人员的CD4检测结果进行了评估。每年对190名HIV-1血清阳性者、80名血清转换者以及495名年龄和性别匹配的HIV血清阴性者进行T淋巴细胞检测。对CD4百分比和CD4计数进行对数转换后，发现其与线性回归曲线拟合良好，R(2)为0.697。发现CD4计数为200个细胞/mm(3)时对应的CD4百分比为9.8%。CD4百分比测定有助于估计CD4计数，但需要进行本地标准化。非洲对应于定义艾滋病的CD4计数的CD4百分比似乎低于工业化国家。
