不同剂量氨基氰对乙醇处理后纹状体中salsolinol形成的影响。
Effect of different doses of cyanamide on striatal salsolinol formation after ethanol treatment.
作者信息
Jamal Mostofa, Ameno Kiyoshi, Ameno Setsuko, Okada Naoko, Ijiri Iwao
机构信息
Department of Forensic Medicine, Faculty of Medicine, Kagawa Medical University, 1750-1 Ikenobe, Miki, Kita, Kagawa 761-0793, Japan.
出版信息
Leg Med (Tokyo). 2003 Mar;5 Suppl 1:S79-82. doi: 10.1016/s1344-6223(02)00083-4.
To assess the dose-dependent effect of cyanamide (CY, a potent aldehyde dehydrogenase inhibitor) on salsolinol release in the striatum, rats were treated with CY (25, 50 and 100 mg/kg) plus ethanol (EtOH,1 g/kg) intraperitoneally. Striatal salsolinol was detected using in vivo microdialysis coupled with high-performance liquid chromatography with an electrochemical detector in free-moving rats, and blood acetaldehyde (AcH) and EtOH were detected using the head-space gas chromatographic method. With the increase in the doses of CY following EtOH, the peak concentrations of striatal salsolinol and blood AcH were increased significantly. Our study indicated that the magnitude of striatal salsolinol levels may depend on the concentration of blood AcH, and that there is a correlation between the blood AcH and striatal salsolinol.
为评估氨基氰（CY，一种有效的乙醛脱氢酶抑制剂）对纹状体中萨索林释放的剂量依赖性作用，将大鼠腹腔注射CY（25、50和100mg/kg）加乙醇（EtOH，1g/kg）进行处理。在自由活动的大鼠中，采用体内微透析结合高效液相色谱-电化学检测器检测纹状体中的萨索林，采用顶空气相色谱法检测血液中的乙醛（AcH）和乙醇。随着乙醇处理后CY剂量的增加，纹状体萨索林和血液AcH的峰值浓度显著升高。我们的研究表明，纹状体萨索林水平的高低可能取决于血液AcH的浓度，并且血液AcH与纹状体萨索林之间存在相关性。
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