Carrington C D, Bolger P M
Division of Toxicological Review and Evaluation, Food and Drug Administration, Washington, DC 20204.
Regul Toxicol Pharmacol. 1992 Dec;16(3):265-72. doi: 10.1016/0273-2300(92)90006-u.
Exposure to lead (Pb) continues to be a source of concern for the U.S. Food and Drug Administration and other federal regulatory agencies. Blood lead levels as low as 10 micrograms Pb/dl have been associated with impaired neurobehavioral development in children and infants. Because of exposure to the fetus, blood lead levels of 10 micrograms Pb/dl are also of concern in pregnant women. Blood lead levels of 30 micrograms Pb/dl have been associated with elevated blood pressure and other adverse effects in adults. The dietary exposure that results in these blood levels of concern were estimated to be 60 micrograms Pb/day for children age 6 years or younger, 150 micrograms Pb/day for children age 7 years or older, 250 micrograms Pb/day for pregnant women, and 750 micrograms Pb/day for adults. A provisional tolerable total dietary intake was derived by applying a factor of 10 to obtain an exposure level that would include some margin of safety.
铅（Pb）暴露仍是美国食品药品监督管理局及其他联邦监管机构关注的一个问题。低至10微克铅/分升的血铅水平已与儿童和婴儿神经行为发育受损相关。由于胎儿会接触到铅，10微克铅/分升的血铅水平在孕妇中也受到关注。30微克铅/分升的血铅水平已与成年人血压升高及其他不良反应相关。据估计，导致这些受关注血铅水平的膳食暴露量分别为：6岁及以下儿童每天60微克铅，7岁及以上儿童每天150微克铅，孕妇每天250微克铅，成年人每天750微克铅。通过应用10的系数得出临时可耐受的膳食总摄入量，以获得一个包含一定安全边际的暴露水平。
