Wälti Monika K, Zimmermann Michael B, Walczyk Thomas, Spinas Giatgen A, Hurrell Richard F
Laboratory for Human Nutrition, Institute of Food Science and Nutrition, Swiss Federal Institute of Technology Zurich, Rüschlikon, Switzerland.
Am J Clin Nutr. 2003 Sep;78(3):448-53. doi: 10.1093/ajcn/78.3.448.
Magnesium deficiency has been associated with type 2 diabetes and may reduce insulin sensitivity and impair glucose tolerance. The etiology of magnesium depletion in diabetes is unclear. Animal studies suggest that diabetes may impair magnesium absorption; however, there are no published data on magnesium absorption in humans with diabetes.
Magnesium absorption from a test meal and the excretion and retention of magnesium were compared between patients with type 2 diabetes and healthy control subjects.
A meal labeled with 10 mg (26)Mg isotopic label was administered, and stool and urine samples were collected for 10 and 6 d, respectively. Apparent absorption was calculated as the difference between the oral dose of (26)Mg isotopic label and the total amount of the isotopic label excreted in the feces. Magnesium retention was calculated from the apparent absorption and urinary excretion of (26)Mg isotopic label in the 6 d after administration.
Mean (+/- SD) values for fractional magnesium absorption in the diabetic patients and the control subjects were 59.3 +/- 7.0% and 57.6 +/- 8.5%, respectively (NS). Mean (+/- SD) urinary magnesium excretion values in the diabetic patients and the control subjects were 11.2 +/- 2.6% and 11.7 +/- 3.8%, respectively (NS); retention values were 54.2 +/- 7.1% and 51.4 +/- 6.1%, respectively (NS).
Dietary magnesium absorption and retention are not impaired in patients with reasonably well-controlled type 2 diabetes.
镁缺乏与2型糖尿病有关，可能会降低胰岛素敏感性并损害糖耐量。糖尿病患者镁缺乏的病因尚不清楚。动物研究表明，糖尿病可能会损害镁的吸收；然而，目前尚无关于糖尿病患者镁吸收的公开数据。
比较2型糖尿病患者和健康对照者从试验餐中吸收镁的情况以及镁的排泄和潴留情况。
给予一顿标记有10毫克（26）镁同位素标记的餐食，分别收集10天的粪便样本和6天的尿液样本。表观吸收量通过口服（26）镁同位素标记剂量与粪便中排泄的同位素标记总量之间的差值计算得出。镁潴留量根据给药后6天内（26）镁同位素标记的表观吸收量和尿排泄量计算得出。
糖尿病患者和对照者的镁吸收分数平均值（±标准差）分别为59.3±7.0%和57.6±8.5%（无显著性差异）。糖尿病患者和对照者的尿镁排泄量平均值（±标准差）分别为11.2±2.6%和11.7±3.8%（无显著性差异）；潴留量分别为54.2±7.1%和51.4±6.1%（无显著性差异）。
血糖控制良好的2型糖尿病患者的膳食镁吸收和潴留未受损害。
