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Decorin inhibition of PDGF-stimulated vascular smooth muscle cell function: potential mechanism for inhibition of intimal hyperplasia after balloon angioplasty.核心蛋白聚糖对血小板衍生生长因子刺激的血管平滑肌细胞功能的抑制作用：球囊血管成形术后抑制内膜增生的潜在机制
Am J Pathol. 2003 Sep;163(3):869-78. doi: 10.1016/S0002-9440(10)63447-5.
2
Curcumin inhibits platelet-derived growth factor-stimulated vascular smooth muscle cell function and injury-induced neointima formation.姜黄素可抑制血小板衍生生长因子刺激的血管平滑肌细胞功能及损伤诱导的内膜增生。
Arterioscler Thromb Vasc Biol. 2006 Jan;26(1):85-90. doi: 10.1161/01.ATV.0000191635.00744.b6. Epub 2005 Oct 20.
3
The cyclolignan picropodophyllin attenuates intimal hyperplasia after rat carotid balloon injury by blocking insulin-like growth factor-1 receptor signaling.环木脂素类鬼臼苦素通过阻断胰岛素样生长因子-1受体信号传导减轻大鼠颈动脉球囊损伤后的内膜增生。
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PPARγ attenuates intimal hyperplasia by inhibiting TLR4-mediated inflammation in vascular smooth muscle cells.过氧化物酶体增殖物激活受体 γ 通过抑制血管平滑肌细胞中 TLR4 介导的炎症反应抑制内膜增生。
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Intracellular calcium transients are necessary for platelet-derived growth factor but not extracellular matrix protein-induced vascular smooth muscle cell migration.细胞内钙瞬变对于血小板衍生生长因子诱导的血管平滑肌细胞迁移是必需的，但对于细胞外基质蛋白诱导的血管平滑肌细胞迁移则不是必需的。
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Blockade of vascular smooth muscle cell proliferation and intimal thickening after balloon injury by the sulfated oligosaccharide PI-88: phosphomannopentaose sulfate directly binds FGF-2, blocks cellular signaling, and inhibits proliferation.硫酸化低聚糖PI - 88对球囊损伤后血管平滑肌细胞增殖和内膜增厚的抑制作用：硫酸化甘露五糖直接结合成纤维细胞生长因子-2，阻断细胞信号传导并抑制增殖。
Circ Res. 2003 May 2;92(8):e70-7. doi: 10.1161/01.RES.0000071345.76095.07. Epub 2003 Apr 10.
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Inhibitory effect of dehydrozingerone on vascular smooth muscle cell function.脱氢姜酮对血管平滑肌细胞功能的抑制作用。
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Activation of vascular smooth muscle cells by TNF and PDGF: overlapping and complementary signal transduction mechanisms.肿瘤坏死因子和血小板衍生生长因子对血管平滑肌细胞的激活：重叠且互补的信号转导机制
Cardiovasc Res. 2005 Feb 15;65(3):674-82. doi: 10.1016/j.cardiores.2004.10.031.
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Targeting endogenous platelet-derived growth factor B-chain by adenovirus-mediated gene transfer potently inhibits in vivo smooth muscle proliferation after arterial injury.通过腺病毒介导的基因转移靶向内源性血小板衍生生长因子B链可有效抑制动脉损伤后体内平滑肌的增殖。
Gene Ther. 1999 Jun;6(6):956-65. doi: 10.1038/sj.gt.3300918.
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Inhibition of vascular smooth muscle cell proliferation and arterial intimal thickening by a novel antiproliferative naphthopyran.一种新型抗增殖萘并吡喃对血管平滑肌细胞增殖和动脉内膜增厚的抑制作用
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Engineering of extracellular matrix from human iPSC-mesenchymal progenitors to enhance osteogenic capacity of human bone marrow stromal cells independent of their age.利用人诱导多能干细胞间充质祖细胞构建细胞外基质，以增强人骨髓基质细胞的成骨能力，且不受其年龄影响。
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The functional role of decorin in corneal neovascularization in vivo.在体研究中 decorin 在角膜新生血管化中的功能作用。
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Neointimal Hyperplasia after Carotid Transection and Anastomosis Surgery is Associated with Degradation of Decorin and Platelet Derived Growth Factor Signaling.颈动脉横断与吻合术后的新生内膜增生与核心蛋白聚糖降解及血小板衍生生长因子信号传导相关。
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IGF-1 Upregulates Biglycan and Decorin by Increasing Translation and Reducing ADAMTS5 Expression.IGF-1 通过增加翻译和减少 ADAMTS5 表达来上调 biglycan 和 decorin。
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本文引用的文献

1
Matrix metalloproteinase inhibition reduces adventitial thickening and collagen accumulation following balloon dilation.基质金属蛋白酶抑制可减少球囊扩张后外膜增厚和胶原积累。
Cardiovasc Res. 2002 Sep;55(4):864-9. doi: 10.1016/s0008-6363(02)00467-4.
2
Arterial elastase activity after balloon angioplasty and effects of elafin, an elastase inhibitor.球囊血管成形术后的动脉弹性蛋白酶活性及弹性蛋白酶抑制剂elafin的作用
Arterioscler Thromb Vasc Biol. 2001 Aug;21(8):1269-74. doi: 10.1161/hq0801.093589.
3
Retroviral overexpression of decorin differentially affects the response of arterial smooth muscle cells to growth factors.核心蛋白聚糖的逆转录病毒过表达对动脉平滑肌细胞对生长因子的反应有不同影响。
Arterioscler Thromb Vasc Biol. 2001 May;21(5):777-84. doi: 10.1161/01.atv.21.5.777.
4
Intimal hyperplasia recurs after removal of PDGF-AB and -BB inhibition in the rat carotid artery injury model.在大鼠颈动脉损伤模型中，去除血小板衍生生长因子-AB和-BB抑制后，内膜增生会复发。
Arterioscler Thromb Vasc Biol. 2000 Nov;20(11):E89-95. doi: 10.1161/01.atv.20.11.e89.
5
Independent modulation of collagen fibrillogenesis by decorin and lumican.核心蛋白聚糖和光蛋白聚糖对胶原纤维形成的独立调节作用
Cell Mol Life Sci. 2000 May;57(5):859-63. doi: 10.1007/s000180050048.
6
Decorin binds near the C terminus of type I collagen.核心蛋白聚糖结合在I型胶原蛋白的C末端附近。
J Biol Chem. 2000 Jul 21;275(29):21801-4. doi: 10.1074/jbc.C000278200.
7
Local expression of bovine decorin by cell-mediated gene transfer reduces neointimal formation after balloon injury in rats.通过细胞介导的基因转移实现牛核心蛋白聚糖的局部表达可减少大鼠球囊损伤后的新生内膜形成。
Circ Res. 2000 Mar 31;86(6):676-83. doi: 10.1161/01.res.86.6.676.
8
Type VIII collagen stimulates smooth muscle cell migration and matrix metalloproteinase synthesis after arterial injury.VIII型胶原蛋白在动脉损伤后刺激平滑肌细胞迁移和基质金属蛋白酶合成。
Am J Pathol. 2000 Feb;156(2):467-76. doi: 10.1016/S0002-9440(10)64751-7.
9
Intragraft platelet-derived growth factor-alpha and transforming growth factor-beta1 during the development of accelerated graft vascular disease after clinical heart transplantation.临床心脏移植后加速性移植血管病发生过程中移植物内血小板衍生生长因子-α和转化生长因子-β1
Transpl Immunol. 1999 Dec;7(4):201-5. doi: 10.1016/s0966-3274(99)80003-3.
10
In vitro growth inhibition of ovarian cancer cells by decorin: synergism of action between decorin and carboplatin.核心蛋白聚糖对卵巢癌细胞的体外生长抑制作用：核心蛋白聚糖与卡铂之间的协同作用。
Cancer Res. 1999 Dec 15;59(24):6192-6.

核心蛋白聚糖对血小板衍生生长因子刺激的血管平滑肌细胞功能的抑制作用：球囊血管成形术后抑制内膜增生的潜在机制

Decorin inhibition of PDGF-stimulated vascular smooth muscle cell function: potential mechanism for inhibition of intimal hyperplasia after balloon angioplasty.

作者信息

Nili Nafiseh, Cheema Asim N, Giordano Frank J, Barolet Alan W, Babaei Saeid, Hickey Reed, Eskandarian Mohammad R, Smeets Mirjam, Butany Jagdish, Pasterkamp Gerard, Strauss Bradley H

机构信息

Roy and Ann Foss Interventional Cardiology Research Program, Terrence Donnelly Heart Centre, St. Michael's Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario, Canada M5B 1W8.

出版信息

Am J Pathol. 2003 Sep;163(3):869-78. doi: 10.1016/S0002-9440(10)63447-5.

DOI:10.1016/S0002-9440(10)63447-5
PMID:12937128
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1868258/
Abstract

Decorin is a small proteoglycan that binds to transforming growth factor-beta (TGF-beta) and inhibits its activity. However, its interaction with platelet-derived growth factor (PDGF), involved in arterial repair after injury, is not well characterized. The objectives of this study were to assess decorin-PDGF and decorin-PDGF receptor (PDGFR) interactions, the in vitro effects of decorin on PDGF-stimulated smooth muscle cell (SMC) functions and the in vivo effects of decorin overexpression on arterial repair in a rabbit carotid balloon-injury model. Decorin binding to PDGF was demonstrated by solid-phase binding and affinity cross-linking assays. Decorin potently inhibited PDGF-stimulated PDGFR phosphorylation. Pretreatment of rabbit aortic SMC with decorin significantly inhibited PDGF-stimulated cell migration, proliferation, and collagen synthesis. Decorin overexpression by adenoviral-mediated gene transfection in balloon-injured carotid arteries significantly decreased intimal cross-sectional area and collagen content by approximately 50% at 10 weeks compared to beta-galactosidase-transfected or balloon-injured, non-transfected controls. This study shows that decorin binds to PDGF and inhibits its stimulatory activity on SMCs by preventing PDGFR phosphorylation. Decorin overexpression reduces intimal hyperplasia and collagen content after arterial injury. Decorin may be an effective therapy for the prevention of intimal hyperplasia after balloon angioplasty.

摘要

核心蛋白聚糖是一种小蛋白聚糖，它能与转化生长因子-β（TGF-β）结合并抑制其活性。然而，其与参与损伤后动脉修复的血小板衍生生长因子（PDGF）之间的相互作用尚未得到充分表征。本研究的目的是评估核心蛋白聚糖与PDGF及核心蛋白聚糖与血小板衍生生长因子受体（PDGFR）的相互作用、核心蛋白聚糖对PDGF刺激的平滑肌细胞（SMC）功能的体外影响，以及核心蛋白聚糖过表达对兔颈动脉球囊损伤模型中动脉修复的体内影响。通过固相结合和亲和交联试验证明了核心蛋白聚糖与PDGF的结合。核心蛋白聚糖能有效抑制PDGF刺激的PDGFR磷酸化。用核心蛋白聚糖预处理兔主动脉SMC可显著抑制PDGF刺激的细胞迁移、增殖和胶原蛋白合成。与β-半乳糖苷酶转染或球囊损伤未转染的对照组相比，通过腺病毒介导的基因转染在球囊损伤的颈动脉中过表达核心蛋白聚糖，在10周时内膜横截面积和胶原蛋白含量显著降低约50%。本研究表明，核心蛋白聚糖与PDGF结合，并通过阻止PDGFR磷酸化来抑制其对SMC的刺激活性。核心蛋白聚糖过表达可减少动脉损伤后的内膜增生和胶原蛋白含量。核心蛋白聚糖可能是预防球囊血管成形术后内膜增生的有效疗法。