Aláez C, Corral L, Hernández Hernández A, Muñiz A, Cruz C, Fernández O, Hernández Ramírez P, Martínez G
Instituto de Hematología e Inmunología, Ciudad de La Habana, Cuba.
Sangre (Barc). 1992 Oct;37(5):391-4.
Oncogenes bcl1 and bcl2 are located in the rupture site of t(11;14) and t(14; 18), respectively. They have been found to rearrange in different B-cell malignancies. A molecular study of oncogenes bcl1 and bcl2 was carried out in 42 patients diagnosed of B-cell chronic lymphoid leukaemia. In 14.3% of the patients the rearrangement affected bcl1, but no differences were found with regard to stage and clinical course between these patients and those without any oncogen rearrangement. In all the patients studied bc12 was in a germinal configuration.
癌基因bcl1和bcl2分别位于t(11;14)和t(14;18)的断裂位点。它们在不同的B细胞恶性肿瘤中发生重排。对42例诊断为B细胞慢性淋巴细胞白血病的患者进行了癌基因bcl1和bcl2的分子研究。14.3%的患者重排影响bcl1，但这些患者与无任何癌基因重排的患者在分期和临床病程方面未发现差异。在所有研究的患者中，bc12处于生发构型。
