Cosimi M F, Casagranda I, Porta C, Moroni M, Orsi R, Nastasi G
Divisione di Anatomia Patologica, Ospedale Civile di Alessandria, Italia.
Sangre (Barc). 1992 Oct;37(5):399-402.
Several reports have shown that the degree of positivity for the AgNOR count can be used to evaluate the aggressiveness of malignancies since it express an increased protein-synthesis activity. This technique was applied to six cases of stage I osseous non-Hodgkin's lymphoma--4 intermediate grade (2 diffuse small, non-cleaved cell and 2 diffuse large, non-cleaved cell lymphomas) and 2 high-grade immunoblastic lymphomas--in order to assess the histologic grade and the number of AgNOR-positive regions. It was noted that survival together with the trend to invade the surrounding soft tissues (i.e., the tumour aggressiveness) correlated with the AgNOR granule count. Both factors were also related with Ki-67 cell-proliferation antibody positivity. Such correlations were even higher than those found with the histologic features conventionally evaluated in the Working Formulation, so they seem to convey more reliable indices of neoplastic growth potential.
多项报告显示，由于AgNOR计数的阳性程度表达了增加的蛋白质合成活性，因此可用于评估恶性肿瘤的侵袭性。该技术应用于6例I期骨非霍奇金淋巴瘤——4例中度分级（2例弥漫性小无裂细胞淋巴瘤和2例弥漫性大无裂细胞淋巴瘤）和2例高度分级免疫母细胞淋巴瘤——以评估组织学分级和AgNOR阳性区域的数量。值得注意的是，生存率以及侵袭周围软组织的趋势（即肿瘤侵袭性）与AgNOR颗粒计数相关。这两个因素也与Ki-67细胞增殖抗体阳性相关。这种相关性甚至高于在工作分类法中常规评估的组织学特征所发现的相关性，因此它们似乎传达了更可靠的肿瘤生长潜能指标。
