Kaufer D
University of Pittsburgh Alzheimer Disease Research Center, Pittsburgh, PA 15213, USA.
Rev Neurol. 2003;37(2):127-30.
Consensus diagnostic criteria for dementia with Lewy bodies (DLB) proposed in 1996 have provided a useful foundation for research in the field. As a clinicopathologically defined entity, DLB has overlapping features of both Alzheimer s disease (AD) and Parkinson's disease (PD). Consensus criteria for DLB distinguish it from PD dementia by the earlier appearance of motor signs in the latter. Studies evaluating the standardized clinical diagnostic criteria for DLB have generally found them to be highly predictive of Lewy body pathology. However, many cases with Lewy body pathology and concomitant pathological features of AD elude clinical detection. Emerging data suggests that AD pathological features mask the clinical expression of concomitant Lewy body pathology, and that DLB and PD dementia may be more similar than distinct.
1996年提出的路易体痴呆（DLB）共识诊断标准为该领域的研究提供了有用的基础。作为一种临床病理定义的实体，DLB具有阿尔茨海默病（AD）和帕金森病（PD）的重叠特征。DLB的共识标准通过运动症状在后者中出现得更早，将其与帕金森病痴呆区分开来。评估DLB标准化临床诊断标准的研究普遍发现，这些标准对路易体病理具有高度预测性。然而，许多伴有路易体病理和AD伴随病理特征的病例难以通过临床检测发现。新出现的数据表明，AD病理特征掩盖了伴随路易体病理的临床表达，并且DLB和帕金森病痴呆可能比人们认为的更为相似。
