López O L
Alzeheimer's disease Research Center, Departamento de Neurologia y Psiquiatría, University of Pittsburgh, Facultad de Medicina, Pittsburgh, PA 15261, USA.
Rev Neurol. 2003;37(2):140-4.
The purpose of this study was to describe the methodology for the diagnosis of mild cognitive impairment (MCI) in the Cardiovascular Health Study Cognition Study (CHS CS).
The CHS CS examined the 3602 participants with detailed neurological, neuropsychological, neuroradiological, and psychiatric testing to identify dementia and MCI in four U.S. populations. The prevalence of MCI was determined for the whole cohort, and specific subtypes of MCI were examined in detail only in Pittsburgh. MCI was classified as follows: MCI Amnestic type (AT): These were patients with documented memory deficits, but otherwise normal cognitive functions. MCI Multiple cognitive deficits type (MCDT): These participants had: a) documented impairments on two tests (>1.5 SD) in a single cognitive domain other than memory, or b) one abnormal domain and one abnormal test in other domain, or c) at least one abnormal test in two different domains. MCI was considered probable when there was no other cause that may explain the cognitive deficits, and possible when there were systemic, neurological, or psychiatric disorders that might have affected cognition.
This study showed that up to 22% of the subjects age 75 or older have MCI. MCI can present in two forms, one with a purely amnestic syndrome, and the other with broader cognitive deficits
本研究旨在描述心血管健康研究认知研究（CHS CS）中轻度认知障碍（MCI）的诊断方法。
CHS CS对3602名参与者进行了详细的神经学、神经心理学、神经放射学和精神病学测试，以在美国的四个人口中识别痴呆和MCI。确定了整个队列中MCI的患病率，仅在匹兹堡详细检查了MCI的特定亚型。MCI分类如下：MCI遗忘型（AT）：这些患者有记录的记忆缺陷，但其他认知功能正常。MCI多认知缺陷型（MCDT）：这些参与者有：a）在除记忆外的单个认知领域的两项测试（>1.5标准差）中有记录的损伤，或b）一个异常领域和其他领域的一项异常测试，或c）在两个不同领域中至少有一项异常测试。当没有其他可能解释认知缺陷的原因时，MCI被认为是可能的，当存在可能影响认知的全身性、神经学或精神疾病时，MCI被认为是可能的。
本研究表明，75岁及以上的受试者中高达22%患有MCI。MCI可以有两种形式，一种是单纯的遗忘综合征，另一种是更广泛的认知缺陷
