用涂钼石墨管电热原子吸收光谱法测定药物中的痕量钯

[Determination of trace palladium in medicament by electric-heated AAS with molybdenum-coated graphite tube].

作者信息

Lin Lin, Han Hua-yun, Chen Ke

机构信息

Department of Chemistry, Zhengzhou University, Zhengzhou 450052, China.

出版信息

Guang Pu Xue Yu Guang Pu Fen Xi. 2002 Jun;22(3):476-7.

PMID:12938339

Abstract

This paper reports a new method for the determination of palladium in exported medicament doxycycline hydrochloride by graphite furnace atomic absorption spectrometry. The optimum conditions for the determination of trace Pd were investigated in details. When the graphite tube was coated with molybdenum, the sensitivity was enhanced and when EDTA was used as the matrix modifier the matrix interference was eliminated efficiently. The result indicates that the detection limit for Pd is 4.6 x 10(-10) g and the relative standard deviation is 4.3%. The method is accurate and rapid and can be used successfully to determine actual samples. The recovery rate of palladium is in the range of 97.1% to 103.3%.

摘要

本文报道了一种用石墨炉原子吸收光谱法测定出口药品盐酸多西环素中钯的新方法。详细研究了测定痕量钯的最佳条件。当石墨管涂覆钼时，灵敏度提高；当使用乙二胺四乙酸（EDTA）作为基体改进剂时，能有效消除基体干扰。结果表明，钯的检测限为4.6×10⁻¹⁰ g，相对标准偏差为4.3%。该方法准确、快速，可成功用于实际样品的测定。钯的回收率在97.1%至103.3%之间。