青藤碱对外周血单个核细胞产生白细胞介素-8、白细胞介素-6、白细胞介素-2的影响。
Effect of Sinomenine on IL-8, IL-6, IL-2 produced by peripheral blood mononuclear cells.
作者信息
Tu S, Hu Y, Lu F
机构信息
Department of Traditional Chinese Medicine, Tongji Hospital, Tongji Medical University, Wuhan 430030.
出版信息
J Tongji Med Univ. 1999;19(4):257-9. doi: 10.1007/BF02886956.
The effect of Sinomenine on IL-8, IL-6, IL-2 and mIL-2R produced by peripheral blood mononuclear cells was investigated by using cell culture, radioimmunoassay and flow cytometry. It was showed that production of IL-8 and mIL-2R was inhibited, but the levels of IL-6 were enhanced by Sinomenine. Our results also demonstrated that Sinomenine did not have any effect on the production of IL-2. The study demonstrated that Sinomenine was able to regulate the production of cytokines. This may be one of the mechanisms by which Sinomenine works on rheumatoid arthritis.
采用细胞培养、放射免疫分析及流式细胞术等方法，研究了青藤碱对外周血单个核细胞产生白细胞介素-8（IL-8）、白细胞介素-6（IL-6）、白细胞介素-2（IL-2）及膜白细胞介素-2受体（mIL-2R）的影响。结果表明，青藤碱可抑制IL-8和mIL-2R的产生，但可提高IL-6的水平。我们的研究结果还表明，青藤碱对IL-2的产生无任何影响。该研究表明，青藤碱能够调节细胞因子的产生。这可能是青藤碱治疗类风湿关节炎的作用机制之一。
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