抗白细胞介素2受体单克隆抗体对类风湿关节炎中活化T细胞的有益作用。
Beneficial effect of monoclonal antibody to interleukin 2 receptor on activated T cells in rheumatoid arthritis.
作者信息
Kyle V, Coughlan R J, Tighe H, Waldmann H, Hazleman B L
机构信息
Rheumatology Research Unit, Addenbrooke's Hospital, Cambridge.
出版信息
Ann Rheum Dis. 1989 May;48(5):428-9. doi: 10.1136/ard.48.5.428.
Abstract
Campath 6, a rat IgG2b monoclonal antibody to the interleukin 2 receptor on activated T cells, was used to treat three patients with active rheumatoid arthritis unresponsive to conventional treatment. Two patients had an excellent response for about three months. There were no significant side effects. The results suggest that activated T cells are of importance in the pathogenesis of rheumatoid arthritis. Although infusions of rat monoclonal antibodies could not be repeated because of the risk of sensitisation, the development of humanised monoclonal antibodies targeted against specific T cell sets would allow repeated courses of treatment to be given.
摘要
坎帕思6是一种针对活化T细胞上白细胞介素2受体的大鼠IgG2b单克隆抗体，用于治疗3例对传统治疗无反应的活动性类风湿关节炎患者。2例患者有大约3个月的良好反应。无明显副作用。结果表明，活化T细胞在类风湿关节炎发病机制中起重要作用。尽管由于致敏风险不能重复输注大鼠单克隆抗体，但开发针对特定T细胞亚群的人源化单克隆抗体将允许重复进行疗程治疗。
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