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The effect of GHRH, GHRP-2 and somatostatin on GH secretion by fetal pituitary.

作者信息

Liu Q, Bai X, Liu K, Lin W, Lei T

机构信息

Department of Pediatrics, Xiehe Hospital, Tongji Medical University, Wuhan 430022.

出版信息

J Tongji Med Univ. 1999;19(4):277-9. doi: 10.1007/BF02886962.

DOI:10.1007/BF02886962
PMID:12938517
Abstract

Growth hormone releasing peptide (GHRP-2) is a synthetic hexapeptide which specifically stimulates secretion of growth hormone (GH) by fetal pituitary somatotrophs through a new membrane receptor, which is different from growth hormone releasing hormone (GHRH) and somatostatin (SMS) receptors. We used cell cultures of human fetal pituitary somatotroph cells to investigate the effect of GHRH, GHRP-2 and somatostatin on GH secretion. The results showed that the mechanism of GHRH/SMS and GHRP-2 was different. This indicated that a different intracellular signal transduction system might also play a crucial role in the regulation of GH secretion.

摘要

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本文引用的文献

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Relationship between GHRP-6 and TPA in the regulation of growth hormone secretion by human pituitary somatotrophinomas.生长激素释放肽-6（GHRP-6）与佛波酯（TPA）在人垂体生长激素瘤调节生长激素分泌中的关系。
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Science. 1996 Aug 16;273(5277):974-7. doi: 10.1126/science.273.5277.974.
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Growth hormone releasing peptide (GHRP-6) stimulates phosphatidylinositol (PI) turnover in human pituitary somatotroph cells.
J Mol Endocrinol. 1995 Feb;14(1):135-8. doi: 10.1677/jme.0.0140135.