Liu Q, Lei T, Adams E F, Buchfedlder M, Fahlbusch R
Department of Pediatrics, Xiehe Hospital, Tongji Medical University, Wuhan.
J Tongji Med Univ. 1997;17(3):132-5. doi: 10.1007/BF02888286.
Growth hormone releasing peptide (GHRP-6) is a synthetic hexapeptide which specifically stimulates secretion of growth hormone (GH) by pituitary somatotrophs. Phorbel ester, 1, 2 tetradecanoylphorbol 13 acetate (TPA) can also stimulate releasing of GH. The precise intracellular mechanism has not been entirely deciphered. We used cell cultures of human pituitary somatotrophinomas to investigate the relation between GHRP-6 and TPA on membrane phosphatidylinositol (PI) turnover and GH secretion. The results showed that the working mechanisms of GHRP-6 and TPA are not identical, although they all can stimulate GH secretion in human pituitary somatotrophinomas. This indicates that PI-PKC signal transduction system may play a crucial role in the regulation of GH secretion.
生长激素释放肽（GHRP - 6）是一种合成六肽，它能特异性刺激垂体生长激素细胞分泌生长激素（GH）。佛波酯，1,2 - 十四酰佛波醇 - 13 - 乙酸酯（TPA）也能刺激GH释放。其确切的细胞内机制尚未完全阐明。我们用人垂体生长激素瘤细胞培养物来研究GHRP - 6和TPA对膜磷脂酰肌醇（PI）周转及GH分泌的关系。结果表明，尽管GHRP - 6和TPA都能刺激人垂体生长激素瘤细胞分泌GH，但其作用机制并不相同。这表明PI - PKC信号转导系统可能在GH分泌调节中起关键作用。
