Dawson Geraldine, Ashman Sharon B, Panagiotides Heracles, Hessl David, Self Joanna, Yamada Emily, Embry Lara
Department of Psychology, Center on Human Development and Disability, University of Washington, Seattle, WA 98195, USA.
Child Dev. 2003 Jul-Aug;74(4):1158-75. doi: 10.1111/1467-8624.00599.
Children of depressed mothers are at risk for behavioral and emotional problems. Infants of depressed mothers exhibit behavioral disturbances and atypical frontal brain activity. The mechanisms by which children develop such vulnerabilities are not clear. Three-year-old children of mothers with (N = 65) and without (N = 59) a history of depression were assessed in terms of behavior problems and brain electrical activity. Children of mothers with chronic depression exhibited lower frontal and parietal brain activation compared with children of mothers without depression and those whose depression remitted. Depressed mothers reported higher contextual risk (e.g., marital discord and stress) and their children had more behavior problems. Children's frontal brain activation and contextual risk level mediated the relation between maternal depression and child behavior problems.
母亲患有抑郁症的孩子有出现行为和情绪问题的风险。母亲患有抑郁症的婴儿表现出行为障碍和非典型的额叶脑活动。儿童产生这些易感性的机制尚不清楚。对有（N = 65）和没有（N = 59）抑郁症病史的母亲的三岁孩子进行了行为问题和脑电活动评估。与没有抑郁症的母亲的孩子以及抑郁症已缓解的母亲的孩子相比，患有慢性抑郁症的母亲的孩子额叶和顶叶脑激活较低。患有抑郁症的母亲报告有更高的情境风险（如婚姻不和和压力），她们的孩子有更多行为问题。儿童的额叶脑激活和情境风险水平介导了母亲抑郁症与儿童行为问题之间的关系。
