the Institute of Child Development at University of Minnesota Twin Cities, Minneapolis, MN 55455, USA.
Department of Psychiatry at Washington University School of Medicine, St. Louis, MO 63110, USA.
Dev Cogn Neurosci. 2024 Dec;70:101469. doi: 10.1016/j.dcn.2024.101469. Epub 2024 Oct 29.
Early life adversity (ELA) has shown to have negative impacts on mental health. One possible mechanism is through alterations in neural emotion processing. We sought to characterize how multiple indices of ELA were related to naturalistic neural socio-emotional processing.
In 521 5-15-year-old participants from the Healthy Brain Network Biobank, we identified scenes that elicited activation of the Default Mode Network (DMN), Ventral Attention Network (VAN), Cingulo-Opercular Network (CON) and amygdala, all of which are networks shown to be associated with ELA. We used linear regression to examine associations between activation and ELA: negative parenting, social status, financial insecurity, neighborhood disadvantage, negative experiences, and parent psychopathology.
We found DMN, VAN, CON and amygdala activation during sad/emotional, bonding, action, conflict, sad, or fearful scenes. Greater inconsistent discipline was associated with greater VAN activation during sad or emotional scenes.
Findings suggest that the DMN, VAN, CON networks and the amygdala support socio-emotional processing consistent with prior literature. Individuals who experienced inconsistent discipline may have greater sensitivity to parent-child separation signals. Since no other ELA-activation associations were found, it is possible that unpredictability may be more strongly associated with complex neural emotion processing than socio-economic status or negative life events.
早期生活逆境（ELA）已被证明对心理健康有负面影响。一种可能的机制是通过改变神经情绪处理。我们试图描述多种 ELA 指标与自然神经社会情感处理的关系。
在来自健康大脑网络生物银行的 521 名 5-15 岁参与者中，我们确定了引发默认模式网络（DMN）、腹侧注意网络（VAN）、扣带-脑岛网络（CON）和杏仁核激活的场景，所有这些网络都与 ELA 相关。我们使用线性回归来检查激活与 ELA 之间的关联：负面养育、社会地位、财务不安全、邻里劣势、负面经历和父母精神病理学。
我们发现 DMN、VAN、CON 和杏仁核在悲伤/情绪、结合、行动、冲突、悲伤或恐惧场景中激活。不一致的纪律处分与悲伤或情绪场景中 VAN 激活增加有关。
研究结果表明，DMN、VAN、CON 网络和杏仁核支持与先前文献一致的社会情感处理。经历不一致纪律处分的个体可能对亲子分离信号更敏感。由于没有发现其他 ELA 激活关联，因此不可预测性可能与复杂的神经情绪处理比社会经济地位或负面生活事件更密切相关。
