Nevorotin A I
Tsitologiia. 1992;34(8):3-27.
Recent data on the structural and molecular organisation of the endoplasmic reticulum (ER) are reviewed. A special attention is paid to the mechanism of soluble and integral membrane protein translocation across the ER bilayer. A model of phospholipid-coupled polypeptide translocation is introduced served to overcome hydrophobic and (or) conformational constraints during the passage of polar amino acid residues within a polar environment of the ER membrane. In addition the mechanisms of diverse covalent and noncovalent post-translocational polypeptide modifications are considered, together with the process of the sorting events among ER-resident polypeptides and those destined to leave the ER domain for the Golgi apparatus.
本文综述了内质网（ER）结构和分子组织的最新数据。特别关注了可溶性和整合膜蛋白跨内质网双层转运的机制。引入了一种磷脂偶联多肽转运模型，以克服极性氨基酸残基在内质网膜极性环境中通过时的疏水和（或）构象限制。此外，还考虑了各种共价和非共价翻译后多肽修饰的机制，以及内质网驻留多肽和那些注定离开内质网区域前往高尔基体的多肽之间的分选过程。
