Pei J M, Zhou S S, Niu G B, Zhu M Z, Zang Y M
Department of Physiology, Fourth Military Medical University, Xian.
Yao Xue Xue Bao. 1992;27(10):721-4.
The effects of potassium ion channel blocker TEA and calcium ion channel blocker verapamil on effective refractory period (ERP) of ischemic ventricular muscle were studied in rabbits. The results showed that ERP of the ventricular muscle in central ischemic zone (CIZ) and border ischemic zone (BIZ) were shortened, respectively, at 10 min and 30 min after coronary occlusion (P < 0.01). The changes of ERP in TEA-treated and verapamil-treated rabbits after coronary occlusion were found to be significantly less than those in untreated rabbits. The results suggest that TEA and verapamil alleviated the degree of ERP shortening after coronary occlusion and may exhibit protective effects on the ischemic myocardium.
研究了钾离子通道阻滞剂四乙铵（TEA）和钙离子通道阻滞剂维拉帕米对兔缺血心室肌有效不应期（ERP）的影响。结果显示，冠状动脉闭塞后10分钟和30分钟时，中心缺血区（CIZ）和边缘缺血区（BIZ）心室肌的ERP分别缩短（P<0.01）。发现冠状动脉闭塞后，TEA处理组和维拉帕米处理组兔的ERP变化明显小于未处理组兔。结果提示，TEA和维拉帕米减轻了冠状动脉闭塞后ERP缩短的程度，可能对缺血心肌具有保护作用。
