Qiu H Y, Wei T X, Zhang Y R, Yan X F, Wei J H
Cardiovascular Disease Institute of He-nan Medical University, Zhengzhou, China.
Zhongguo Yao Li Xue Bao. 1993 May;14(3):260-2.
Effects of ranitidine (Ran) on ventricular refractory period and fibrillation threshold of normal and ischemic ventricle were investigated in pentobarbitone anesthetized rabbits. In saline-treated rabbits, relative refractory period (RRP) and effective refractory period (ERP) were shortened from 132 +/- 24 to 126 +/- 25 ms (n = 10, P < 0.05) and from 118 +/- 22 to 108 +/- 27 ms (n = 10, P < 0.05) in boundary zone of ventricular ischemic regions, respectively. The ventricular fibrillation threshold (VFT) was decreased from 5.5 +/- 1.4 to 2.8 +/- 1.1 V (n = 10, P < 0.01) after coronary artery ligation (CAL). Ran (25 mg.kg-1, i.v.) not only prevented these changes, but also lengthened RRP from 123 +/- 14 to 136 +/- 10 ms (P < 0.05) and ERP from 111 +/- 16 to 126 +/- 12 ms (P < 0.05), and increased VFT from 4.7 +/- 0.8 to 7.4 +/- 1.8 V (P < 0.01) in normal ventricle. The results suggest that Ran may have anti-arrhythmic effects in rabbits.
在戊巴比妥麻醉的家兔中，研究了雷尼替丁（Ran）对正常和缺血心室的心室不应期及颤动阈值的影响。在生理盐水处理的家兔中，心室缺血区域边界区的相对不应期（RRP）和有效不应期（ERP）分别从132±24毫秒缩短至126±25毫秒（n = 10，P < 0.05）以及从118±22毫秒缩短至108±27毫秒（n = 10，P < 0.05）。冠状动脉结扎（CAL）后，心室颤动阈值（VFT）从5.5±1.4伏降至2.8±1.1伏（n = 10，P < 0.01）。静脉注射Ran（25毫克·千克-1）不仅可防止这些变化，还能使正常心室的RRP从123±14毫秒延长至136±10毫秒（P < 0.05），ERP从111±16毫秒延长至126±12毫秒（P < 0.05），并使VFT从4.7±0.8伏提高至7.4±1.8伏（P < 0.01）。结果表明，Ran可能对家兔具有抗心律失常作用。
