Fujisawa T, Kuboki T, Kasai T, Sonoyama W, Kojima S, Uehara J, Komori C, Yatani H, Hattori T, Takigawa M
Oral and Maxillofacial Rehabilitation, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan.
J Dent Res. 2003 Sep;82(9):731-5. doi: 10.1177/154405910308200914.
Although excessive mechanical stress is assumed to be one of the factors contributing to pathogenesis of temporomandibular joint (TMJ) osteoarthritis (OA), no pure mechanical-stress-induced OA model has been developed without surgical manipulation or puncture of the joint cavity. The purpose of this study was to establish a genuine mechanical-stress-induced OA model of the rabbit TMJ. In the experimental rabbits, repetitive, forced jaw-opening, 3 hrs/day for 5 days, was applied with the use of a general anesthesia protocol. By histological assessment of the TMJ articular tissues, partial eburnation of the articular cartilage, reactive marginal proliferation of the articular cartilage chondrocytes, and nested proliferation of chondrocytes in the subchondral bone area were observed at 7 days after the repetitive, forced-jaw-opening period. These results suggest that the repetitive, forced-jaw-opening protocol without surgical intervention can induce evident OA-like lesions in the rabbit TMJ, and this OA model may greatly contribute to the elucidation of the cartilage degradation mechanism in TMJ OA.
尽管过度的机械应力被认为是导致颞下颌关节（TMJ）骨关节炎（OA）发病的因素之一，但尚未建立一种无需手术操作或关节腔穿刺的单纯机械应力诱导的OA模型。本研究的目的是建立一种真正的兔TMJ机械应力诱导的OA模型。在实验兔中，采用全身麻醉方案，每天强制重复开口3小时，持续5天。通过对TMJ关节组织的组织学评估，在重复强制开口期后的7天，观察到关节软骨部分磨损、关节软骨软骨细胞反应性边缘增殖以及软骨下骨区域软骨细胞巢状增殖。这些结果表明，无需手术干预的重复强制开口方案可在兔TMJ中诱导明显的OA样病变，该OA模型可能对阐明TMJ OA中的软骨降解机制有很大帮助。
