[N-(4-取代氨基-4-氧代丁酰基)-N-取代甘氨酸的合成]
[Synthesis of N-(4-substituted amino-4-oxobutyryl)-N-substituted glycines].
作者信息
Wu Y, Cai C Y, Gong K S
机构信息
School of Pharmacy, West China University of Medical Sciences, Chengdu.
出版信息
Yao Xue Xue Bao. 1992;27(9):717-20.
PMID:1293947
Abstract
Nine N-(4-substituted amino-4-oxobutyryl)-N-substituted glycines expected to have inhibitory activity on angiotensin-converting enzyme were synthesized. All of the title compounds and their t-butyl esters were unreported in the literature. In preliminary test in rats, compounds V2, V6 and V7 showed marked hypotensive activity.
摘要
合成了9种预计对血管紧张素转换酶具有抑制活性的N-(4-取代氨基-4-氧代丁酰基)-N-取代甘氨酸。所有标题化合物及其叔丁酯在文献中均未见报道。在大鼠的初步试验中，化合物V2、V6和V7显示出明显的降压活性。
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