Chen Y M, Cai C Y, Gong K S
Yao Xue Xue Bao. 1989;24(12):887-94.
This paper reports the synthesis of nine N-(4-carbethoxy-4-substituted butyryl)-N-substituted glycines and their corresponding t-butyl esters. The former were expected to have inhibitory activity of angiotensin-converting enzyme. All of the compounds mentioned above were unreported in the literature. In preliminary test in rats, compounds VII7 and VII9 showed marked hypotensive activity.
本文报道了9种N-(4-乙氧羰基-4-取代丁酰基)-N-取代甘氨酸及其相应叔丁酯的合成。预计前者具有血管紧张素转换酶抑制活性。上述所有化合物在文献中均未见报道。在大鼠的初步试验中，化合物VII7和VII9表现出显著的降压活性。
