de Bruijn J M, Kruger T F, van der Merwe J P, Stander F S, Lombard C J
Reproductive Biology Unit, Department of Obstetrics and Gynaecology, Tygerberg Hospital and Stellenbosch University, Tygerberg, W Cape.
S Afr Med J. 2003 Jul;93(7):532-6.
To identify the factors that most significantly affected pregnancy rates in a gamete intrafallopian transfer (GIFT) programme.
A total of 863 GIFT cycles were analysed retrospectively. The variables found to be associated significantly with pregnancy were then used to obtain multivariate analysis using logistical regression.
Overall and ongoing pregnancy rates were significantly better in patients < or = 38 years than in patients > 38 years (37.3% and 28.4% v. 23.7% and 11.0% respectively), and age was positively associated with success after GIFT (odds ratio (OR) 1.87, 95% confidence interval (CI): 1.22-2.85). Metaphase I (MI) oocytes were negatively associated with pregnancy (OR 1.54, 95% CI: 0.28-1.04). The highest pregnancy rates occurred when 3 metaphase II (MII) oocytes were transferred (39.8%, OR 7.51, 95% CI: 1.74-32.42). With regard to sperm morphology, overall pregnancy rates of 25.5% (< or = 4% normal forms) and 37.2% (> 4% normal forms) were obtained. Morphology of > 4% normal forms was positively associated with pregnancy (OR 1.58, 95% CI: 1.04-2.42).
The results of this study suggest that the most important factors influencing pregnancy rates in a GIFT programme are the woman's age and those factors pertaining to the characteristics of the gametes. Considering the emotional and financial costs it is important to relate this information to all prospective participants in a GIFT programme.
确定在配子输卵管内移植（GIFT）项目中对妊娠率影响最显著的因素。
回顾性分析了总共863个GIFT周期。然后将发现与妊娠显著相关的变量用于进行逻辑回归的多变量分析。
年龄≤38岁的患者总体妊娠率和持续妊娠率显著高于年龄＞38岁的患者（分别为37.3%和28.4%对23.7%和11.0%），并且年龄与GIFT术后的成功率呈正相关（优势比（OR）为1.87，95%置信区间（CI）：1.22 - 2.85）。中期I（MI）卵母细胞与妊娠呈负相关（OR为1.54，95%CI：0.28 - 1.04）。移植3个中期II（MII）卵母细胞时妊娠率最高（39.8%，OR为7.51，95%CI：1.74 - 32.42）。关于精子形态，正常形态≤4%的患者总体妊娠率为25.5%，正常形态＞4%的患者总体妊娠率为37.2%。正常形态＞4%与妊娠呈正相关（OR为1.58，95%CI：1.04 - 2.42）。
本研究结果表明，影响GIFT项目妊娠率的最重要因素是女性年龄以及与配子特征相关的因素。考虑到情感和经济成本，将此信息告知所有GIFT项目的潜在参与者很重要。
