Alcaraz Calderón Luciana, Escárcega Barbosa David, Castrejón Vázquez María Isabel, Galicia Tapia Jorge, Cano Altamirano Silvia, Angeles Rivera Juan Manuel, Zayde Palma Nájera Iliana, Miranda Feria Alfonso Javier
Servicio de Inmunologia Clinica y Alergia, Centro Médico Nacional 20 de Noviembre Coyoacán y Félix Cuevas, col. Del Valle, México, DF, CP 03229.
Rev Alerg Mex. 2003 May-Jun;50(3):96-102.
Chronic urticaria is characterized by erythematous wheals during more than 6 weeks. In 47% of the patients it is associated to Helicobacter pylori infection; in 50%, to antibodies (Abs) against the high affinity receptor of the IgE, and in 12 to 20% to antithyroid's antibodies (antithyroglobuline, mychrosomals) and, from these, 25% have alterations of the thyroid function.
To determine the presence of the anti-Helicobacter pylori and anttihyroids antibodies and the high affinity anti-receptor of the IgE in healthy subjects and patients with chronic urticaria.
Eighty subjects were included: 40 healthy subjects and 40 patients whit diagnosis of chronic urticaria. In all of them a blood sample was extracted to the determination of the antibodies and skin test applications with autologous serum to determine the antibody of the high affinity anti-receptor of IgE. For the analysis of the results descriptive statistics was used (central tendency measures, frequencies, means, averages and percentages), as well as multiple correlations and inferential analyses.
Anti-Helicobacter pylori, antithyroid (antithyroglobulin, microsomal) antibodies and the skin test with autologous serum (antibody of the high affinity anti-receptor of IgE) were negative in the healthy group (mean age: 41 years, 36 women, 90%). Of the 40 patients with chronic urticaria (mean age: 42 years, 36 women, 90%), the frequency of the antibody of high affinity anti-receptor of the IgE was: 5 patients with negative skin test (12.5%), 1 (2.5%)+, 7 (17.5%)++, 9 (22.5%)+++, 18 (45%)++++. The anti-Helicobacter pylori antibodies were positive in 30 (75%) patients and negative in 10 (25%). The antithyroid's antibodies were as follows: antithyroglobulin: 4 (10%) positive, microsomal: 4 (10%) positive. The concomitant diseases found were: hypothyroidism (3, 7.5%) mixed rhinitis (2.5%) and autoimmunity 2 (5%).
The test skin with autologous serum to determine the IgG antibody against the high affinity receptor of IgE is a simple and low-cost procedure leading to determine the cause of the idiopathic chronic urticaria in a high percentage of patients. As reported in literature, the Helicobacter pylori infection documented by the detection of the IgM antibodies against Helicobacter pylori is frequent in patients with chronic urticaria, which is important due to it could be implied in the diagnosis and treatment.
慢性荨麻疹的特征是红斑风团持续超过6周。47%的患者与幽门螺杆菌感染有关；50%与针对IgE高亲和力受体的抗体（Abs）有关，12%至20%与抗甲状腺抗体（抗甲状腺球蛋白、微粒体）有关，其中25%有甲状腺功能改变。
确定健康受试者和慢性荨麻疹患者中抗幽门螺杆菌抗体、抗甲状腺抗体以及IgE高亲和力抗受体的存在情况。
纳入80名受试者：40名健康受试者和40名诊断为慢性荨麻疹的患者。对所有受试者抽取血样以测定抗体，并应用自体血清进行皮肤试验以测定IgE高亲和力抗受体抗体。对于结果分析，使用描述性统计（集中趋势测量、频率、均值、平均数和百分比）以及多重相关性和推断性分析。
健康组（平均年龄：41岁，36名女性，占90%）中抗幽门螺杆菌、抗甲状腺（抗甲状腺球蛋白、微粒体）抗体以及自体血清皮肤试验（IgE高亲和力抗受体抗体）均为阴性。在40例慢性荨麻疹患者（平均年龄：42岁，36名女性，占90%）中，IgE高亲和力抗受体抗体的频率为：5例皮肤试验阴性（12.5%），1例（2.5%）+，7例（17.5%）++，9例（22.5%）+++；18例（45%）++++。30例（75%）患者的抗幽门螺杆菌抗体为阳性，10例（25%）为阴性。抗甲状腺抗体情况如下：抗甲状腺球蛋白：4例（10%）阳性，微粒体：4例（10%）阳性。发现的伴随疾病有：甲状腺功能减退（3例，7.5%）、混合性鼻炎（2.5%）和自身免疫性疾病2例（5%）。
应用自体血清进行皮肤试验以测定针对IgE高亲和力受体的IgG抗体是一种简单且低成本的方法，可在很大比例的患者中确定特发性慢性荨麻疹的病因。如文献报道，通过检测抗幽门螺杆菌IgM抗体所记录的幽门螺杆菌感染在慢性荨麻疹患者中很常见，这在诊断和治疗中具有重要意义。
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