幽门螺杆菌感染与慢性特发性荨麻疹自体血清皮肤试验之间缺乏相关性。
Lack of correlation between Helicobacter pylori infection and autologous serum skin test in chronic idiopathic urticaria.
作者信息
Başkan Emel Bülbül, Türker Tugba, Gülten Macit, Tunali Sükran
机构信息
Department of Dermatology, Uludag University Medical Faculty, Bursa, Turkey.
出版信息
Int J Dermatol. 2005 Dec;44(12):993-5. doi: 10.1111/j.1365-4632.2005.02280.x.
BACKGROUND
There are controversial reports about the direct role of Helicobacterpylori infection in chronic idiopathic urticaria. The indirect role of H. pylori infection in the induction of pathogenetic antibodies is not fully elucidated either. This study aims to reveal the association of H. pylori infection with autologous serum skin test positivity in chronic idiopathic urticaria (CIU) patients.
METHODS
A total of 47 patients (35 women, 12 men, age range 17-65 years) diagnosed as CIU were included in the study. Autologous serum skin test was performed on all patients. The patients were examined with a commercially available ELISA test for H. pylori-specific antibodies. Gastroscopy with mucosal biopsy and rapid urease tests were proposed to verify the presence of H. pylori infection.
RESULTS
Helicobacter pylori infection was detected in 33 of the 47 patients (70%). No significant relation was found between the autologous serum skin test positivity and the serological and histopathological presence of H. pylori infection.
CONCLUSION
The results of our study suggest that chronic H. pylori infection does not appear to have a role in the induction of autoantibodies in CIU.
背景
关于幽门螺杆菌感染在慢性特发性荨麻疹中的直接作用，存在有争议的报道。幽门螺杆菌感染在致病性抗体诱导中的间接作用也尚未完全阐明。本研究旨在揭示幽门螺杆菌感染与慢性特发性荨麻疹（CIU）患者自体血清皮肤试验阳性之间的关联。
方法
本研究共纳入47例诊断为CIU的患者（35例女性，12例男性，年龄范围17 - 65岁）。对所有患者进行自体血清皮肤试验。采用市售ELISA试验检测患者幽门螺杆菌特异性抗体。建议进行胃镜检查及黏膜活检和快速尿素酶试验以证实幽门螺杆菌感染的存在。
结果
47例患者中有33例（70%）检测到幽门螺杆菌感染。自体血清皮肤试验阳性与幽门螺杆菌感染的血清学及组织病理学表现之间未发现显著相关性。
结论
我们的研究结果表明，慢性幽门螺杆菌感染似乎在CIU自身抗体的诱导中不起作用。
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