Bogavac-Stanojevic Natasa, Djurovic Srdjan, Jelic-Ivanovic Zorana, Spasojevic-Kalimanovska Vesna, Kalimanovska-Ostric Dimitra
Institute of Medical Biochemistry, Faculty of Pharmacy, Belgrade, Yugoslavia.
Clin Chem Lab Med. 2003 Jul;41(7):893-8. doi: 10.1515/CCLM.2003.135.
Transforming growth factor-beta1 (TGF-beta1) is involved in different physiological and pathological processes, including atherogenesis. High plasma lipoprotein(a) (Lp(a)) concentration is an established independent risk factor that may interfere with the plasmin-mediated TGF-beta1 activation. Both Lp(a) and TGF-beta1 are thought to influence the expression of cellular adhesion molecules (CAMs), also involved in the process of atherogenesis. Whereas many studies confirmed the association between high plasma Lp(a) levels and coronary artery disease (CAD), conflicting results were obtained in different studies in which the changes of TGF-beta1 and CAM concentrations in CAD patients were investigated. The aim of this case-control study was to explore the association of circulating TGF-beta1, Lp(a) and CAMs (intracellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin) levels with the occurrence and severity of angiographically assessed coronary artery disease. Plasma TGF-beta1, Lp(a), ICAM-1, VCAM-1 and E-selectin concentrations were measured in 100 patients with angiographically assessed CAD and 100 healthy blood donors matched according to age and gender. Lp(a) and TGF-beta1 were significantly higher in patients than in healthy controls (p < 0.001 and p < 0.01, respectively), but no significant correlation between the TGF-beta1 and Lp(a) values was found. The CAM concentrations obtained in CAD patients did not differ significantly as compared with the corresponding values in the controls. None of the measured parameters were influenced by the severity of CAD.
转化生长因子-β1（TGF-β1）参与包括动脉粥样硬化形成在内的多种生理和病理过程。高血浆脂蛋白(a)（Lp(a)）浓度是一个已确定的独立危险因素，可能会干扰纤溶酶介导的TGF-β1激活。Lp(a)和TGF-β1都被认为会影响细胞黏附分子（CAMs）的表达，而细胞黏附分子也参与动脉粥样硬化形成过程。尽管许多研究证实了高血浆Lp(a)水平与冠状动脉疾病（CAD）之间的关联，但在不同研究中，对CAD患者TGF-β1和CAM浓度变化的调查结果却相互矛盾。本病例对照研究的目的是探讨循环中的TGF-β1、Lp(a)和CAMs（细胞间黏附分子-1（ICAM-1）、血管细胞黏附分子-1（VCAM-1）和E-选择素）水平与血管造影评估的冠状动脉疾病的发生和严重程度之间的关联。对100例经血管造影评估患有CAD的患者和100名根据年龄和性别匹配的健康献血者测定了血浆TGF-β1、Lp(a)、ICAM-1、VCAM-1和E-选择素浓度。患者的Lp(a)和TGF-β1显著高于健康对照组（分别为p < 0.001和p < 0.01），但未发现TGF-β1和Lp(a)值之间存在显著相关性。CAD患者的CAM浓度与对照组的相应值相比无显著差异。所测参数均不受CAD严重程度的影响。
