Lim J T, Goh C L
National Skin Centre, Singapore.
Australas J Dermatol. 1992;33(2):87-91. doi: 10.1111/j.1440-0960.1992.tb00086.x.
This is a retrospective study of the cure rates of forty patients with subungual and periungual viral warts treated with carbon dioxide laser vapourisation (total of 69 lesions). 70.6% (48/68) lesions had failed treatment with cryotherapy and/or electrocautery treatment previously. 20/68 were treated with CO2 laser vapourisation as a first line treatment. The overall cure rate over 10 months follow-up period was 57.4% (39/68). Most recurrences (24/25) occurred within the first 3 months of vapourisation. The carbon dioxide laser vapourisation cure rate for warts in which previous cryotherapy and/or electrocautery had failed was 47.9% whereas those treated with carbon dioxide laser vapourisation as a first line treatment had a cure rate of 80% (p = 0.043). Subungual warts responded slightly better with a cure rate of 64.7% compared with periungual warts (54.9%) (n.s.). The carbon dioxide laser vapourisation cure rate for recurrent subungual and periungual warts (which failed previous carbon dioxide laser vapourisation) was 73.3% (11/15). Our findings appeared to indicate that periungual and subungual warts can be eradicated by CO2 laser vapourisation. Recurrent warts can be effectively eradicated by further vapourisation. Recalcitrant periungual and subungual warts which have previously failed to respond to cryotherapy and/or electrocautery can be effectively eradicated with CO2 laser vapourisation.
这是一项回顾性研究，对40例甲下及甲周病毒疣患者采用二氧化碳激光汽化术进行治疗（共69处病损）。70.6%（48/68）的病损此前冷冻治疗和/或电灼治疗失败。68例中有20例采用二氧化碳激光汽化术作为一线治疗。在10个月的随访期内，总体治愈率为57.4%（39/68）。大多数复发（24/25）发生在汽化后的前3个月内。对于此前冷冻治疗和/或电灼治疗失败的疣，二氧化碳激光汽化术的治愈率为47.9%，而作为一线治疗采用二氧化碳激光汽化术的治愈率为80%（p = 0.043）。甲下疣的反应稍好，治愈率为64.7%，而甲周疣的治愈率为54.9%（无统计学差异）。复发性甲下及甲周疣（此前二氧化碳激光汽化术失败）的二氧化碳激光汽化术治愈率为73.3%（11/15）。我们的研究结果似乎表明，甲周和甲下疣可通过二氧化碳激光汽化术根除。复发性疣可通过进一步汽化有效根除。此前对冷冻治疗和/或电灼治疗无反应的顽固性甲周和甲下疣可通过二氧化碳激光汽化术有效根除。
