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用二苯环丙烯酮进行局部免疫疗法在治疗甲周疣方面有效且是首选方法。

Topical immunotherapy with diphenylcyclopropenone is effective and preferred in the treatment of periungual warts.

作者信息

Choi Yunseok, Kim Do Hun, Jin Sang Yun, Lee Ai-Young, Lee Seung Ho

机构信息

Department of Dermatology, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, Goyang, Korea.

出版信息

Ann Dermatol. 2013 Nov;25(4):434-9. doi: 10.5021/ad.2013.25.4.434. Epub 2013 Nov 30.

DOI:10.5021/ad.2013.25.4.434
PMID:24371390
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3870211/
Abstract

BACKGROUND

There exists a treatment challenge with periungual warts. Topical immunotherapy with diphenylcyclopropenone (DPCP) has recently been reported to be an effective treatment for recalcitrant warts, including periungual types.

OBJECTIVE

We aimed to evaluate the effectiveness and preference of topical immunotherapy with DPCP in treating periungual warts.

METHODS

Twenty-seven patients with periungual warts who were treated with DPCP immunotherapy (2007 through 2010; Dongguk University Ilsan Hospital, Goyang, Korea) were retrospectively recruited. Other treatment modalities were also used in some patients. Lesions were grouped into the types according to the following locations: proximal nail fold, lateral nail fold and hyponychium. Total and group clearance rates as well as treatment periods according to location and disease duration were evaluated. A patient questionnaire was performed to assess the satisfaction for the treatments in those who received multiple therapies.

RESULTS

Total success rates were 85% (by subjects) and 91% (by individual lesions). Success rate and treatment period for proximal nail fold type seemed more desirable than other locations. Success rate decreased and treatment period increased as disease duration increased. The questionnaire revealed a significantly higher satisfaction rate for DPCP immunotherapy than for cryotherapy and pulsed-dye laser.

CONCLUSION

Topical immunotherapy with DPCP is an effective and preferred method in the treatment of periungual warts.

摘要

背景

甲周疣的治疗存在挑战。最近有报道称，用二苯基环丙烯酮（DPCP）进行局部免疫疗法是治疗顽固性疣（包括甲周疣类型）的有效方法。

目的

我们旨在评估用DPCP进行局部免疫疗法治疗甲周疣的有效性和患者偏好。

方法

回顾性招募了27例接受DPCP免疫疗法治疗的甲周疣患者（2007年至2010年；韩国高阳东国大学一山医院）。部分患者还采用了其他治疗方式。根据以下部位将皮损分为不同类型：甲近端皱襞、甲侧皱襞和甲下。评估了总体和各类型的清除率以及根据部位和病程的治疗时间。对接受多种治疗的患者进行了问卷调查，以评估其对治疗的满意度。

结果

总体成功率为85%（按患者）和91%（按单个皮损）。甲近端皱襞型的成功率和治疗时间似乎比其他部位更理想。随着病程延长，成功率降低，治疗时间增加。问卷调查显示，DPCP免疫疗法的满意度显著高于冷冻疗法和脉冲染料激光。

结论

用DPCP进行局部免疫疗法是治疗甲周疣的一种有效且患者更偏好的方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/200a/3870211/6a8a25765d99/ad-25-434-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/200a/3870211/8e831bca3edf/ad-25-434-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/200a/3870211/b9e3a534bcfb/ad-25-434-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/200a/3870211/00460b856a4f/ad-25-434-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/200a/3870211/6a8a25765d99/ad-25-434-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/200a/3870211/8e831bca3edf/ad-25-434-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/200a/3870211/b9e3a534bcfb/ad-25-434-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/200a/3870211/00460b856a4f/ad-25-434-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/200a/3870211/6a8a25765d99/ad-25-434-g004.jpg

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