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再缩窄与患者免于再次干预——对布拉迪斯拉发儿童医院心脏外科接受主动脉缩窄手术患者的研究

Recoarctation and patients' freedom from re-intervention--a study of patients undergoing surgery for coarctation of the aorta at the Department of Cardiac Surgery of the Children's University Hospital, Bratislava.

作者信息

Omeje I C, Kaldararova M, Sagat M, Sojak V, Nosal M, Siman J, Hraska V

机构信息

Department of Cardiac Surgery, Children's University Hospital, Bratislava, Slovakia.

出版信息

Bratisl Lek Listy. 2003;104(3):115-9.

Abstract

BACKGROUND

Many children and young adults have undergone surgery for coarctation of the aorta. Individual surgical techniques employed in the treatment of patients and their effects on incidence of recoarctation were reviewed.

METHODS AND DATA

Over the last ten years, a total of 201 cases of aortic coarctation were surgically treated at our department. The three forms of coarctation of the aorta recognized by the Society for Cardiothoracic Surgeons namely: isolated coarctation, coarctation with ventricular septal defects and coarctation with complex cardiac anomalies, were represented.

RESULTS

19 cases of recoarctation were recorded over the period of follow-up, representing 10% of all operated patients. On univariate analysis, the risk of recoarctation was closely linked with the following variables: use of resection and end-to-end anastomosis (p=0.01), age at operation less than one month (p=0.0002) and weight at operation less than 3 kg (p=0.01). The risk of recoarctation was found to be highest when resection and end-to-end anastomosis was employed in neonates (p<0.0001). Most cases of recoarctation as shown by the Kaplan-Meier plot occurred within the first year after surgery.

CONCLUSION

The use of simple resection and end-to-end anastomosis in neonates is associated with a high risk of recoarctation. Hence, our preferred surgical technique in neonates is the extended resection and end-to-end anastomosis, which is associated with a considerably lower risk of recoarctation in this age group. (Tab. 4, Fig. 5, Re. 7)

摘要

背景

许多儿童和年轻成人接受了主动脉缩窄手术。回顾了治疗患者所采用的个体手术技术及其对再缩窄发生率的影响。

方法和数据

在过去十年中,我们科室共对201例主动脉缩窄患者进行了手术治疗。涵盖了心胸外科医师协会认可的三种主动脉缩窄形式,即:孤立性缩窄、合并室间隔缺损的缩窄以及合并复杂心脏畸形的缩窄。

结果

在随访期间记录到19例再缩窄病例,占所有手术患者的10%。单因素分析显示,再缩窄风险与以下变量密切相关:采用切除及端端吻合术(p = 0.01)、手术年龄小于1个月(p = 0.0002)以及手术体重小于3千克(p = 0.01)。发现当在新生儿中采用切除及端端吻合术时,再缩窄风险最高(p < 0.0001)。如Kaplan-Meier曲线所示,大多数再缩窄病例发生在术后第一年。

结论

在新生儿中使用简单的切除及端端吻合术与再缩窄的高风险相关。因此,我们在新生儿中首选的手术技术是扩大切除及端端吻合术,该技术在这个年龄组中再缩窄风险显著较低。(表4,图5,参考文献7)

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