Mirzaei S, Rodrigues M, Koehn H, Knoll P, Bruecke Th
Ludwig Boltzmann Institute of Nuclear Medicine, Wilhelminenspital, Vienna, Austria.
Eur J Neurol. 2003 Sep;10(5):573-5. doi: 10.1046/j.1468-1331.2003.00650.x.
A reliable assessment of dementia is essential for a differentiated treatment. Recent studies have demonstrated a poor accuracy of clinical criteria for diagnosis of Lewy body dementia. Diffuse Lewy body disease (LBD) is the second most common cause of senile degenerative dementia and is characterized histologically by the occurrence of Lewy bodies in allocortical, neocortical and subcortical structures. Seven male patients (mean age 81 years) with clinically suspected diffuse LBD were investigated with 18F-fluorodeoxyglucose (FDG)-PET using a Siemens ECAT-ART PET-scanner. The 18F-FDG-PET showed a diffuse glucose hypometabolism in the entire cerebral cortex with relative sparing of the primary sensory-motor cortex in all patients. This diffuse metabolic impairment in the entire cortex with relative sparing of central region seems to be a typical pattern for LBD, distinct from Alzheimer's disease.
对痴呆症进行可靠评估对于差异化治疗至关重要。最近的研究表明，路易体痴呆症临床诊断标准的准确性较差。弥漫性路易体病（LBD）是老年退行性痴呆的第二大常见病因，其组织学特征是在allocortical、新皮质和皮质下结构中出现路易体。使用西门子ECAT-ART正电子发射断层扫描仪，对7名临床疑似弥漫性LBD的男性患者（平均年龄81岁）进行了18F-氟脱氧葡萄糖（FDG）-PET检查。18F-FDG-PET显示，所有患者的整个大脑皮层均出现弥漫性葡萄糖代谢减低，初级感觉运动皮层相对保留。整个皮层的这种弥漫性代谢损害且中央区域相对保留似乎是LBD的典型模式，有别于阿尔茨海默病。
