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同基因移植物抗宿主病:两例报告及文献复习

Syngeneic graft-versus-host disease: a report of two cases and literature review.

作者信息

Latif T, Pohlman B, Kalaycio M, Sobecks R, Hsi E D, Andresen S, Bolwell B J

机构信息

Department of Hematology and Medical Oncology, Taussig Cancer Center, Cleveland, OH 44195, USA.

出版信息

Bone Marrow Transplant. 2003 Sep;32(5):535-9. doi: 10.1038/sj.bmt.1704171.

DOI:10.1038/sj.bmt.1704171
PMID:12942102
Abstract

Rappeport et al first reported the clinical syndrome of graft-versus-host disease (GVHD) in syngeneic bone marrow transplant patients. Recently, there have been more reports of a GVHD-like syndrome in syngeneic bone marrow transplant patients (SGVHD) that may result in significant clinical morbidity. A total of 17 cases of SGVHD in syngeneic bone marrow transplant patients have been reported to date in the medical literature. The current report reviews these cases and presents two additional cases of severe SGVHD that have occurred at our institution.

摘要

拉佩波特等人首次报道了同基因骨髓移植患者的移植物抗宿主病(GVHD)临床综合征。最近,有更多关于同基因骨髓移植患者中类似GVHD综合征(SGVHD)的报道,这种综合征可能导致严重的临床发病率。迄今为止,医学文献中已报道了17例同基因骨髓移植患者的SGVHD病例。本报告回顾了这些病例,并介绍了在我们机构发生的另外两例严重SGVHD病例。

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引用本文的文献

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Long-term skin-resident memory T cells proliferate in situ and are involved in human graft-versus-host disease.长期驻留皮肤的记忆T细胞在原位增殖,并参与人类移植物抗宿主病。
Sci Transl Med. 2020 Nov 18;12(570). doi: 10.1126/scitranslmed.abb7028.