神经母细胞瘤中肌动蛋白结合蛋白原肌球蛋白1的功能分析
Functional analysis of the actin-binding protein, tropomyosin 1, in neuroblastoma.
作者信息
Yager M L, Hughes J A I, Lovicu F J, Gunning P W, Weinberger R P, O'Neill G M
机构信息
The Oncology Research Unit, The Children's Hospital at Westmead, Locked Bag 4001, Westmead 2145, NSW, Australia.
出版信息
Br J Cancer. 2003 Sep 1;89(5):860-3. doi: 10.1038/sj.bjc.6601201.
Tropomyosin 1 (TM1) is downregulated in a number of transformed cell types, and exogenous expression of TM1 can restore actin organisation and reverse cellular transformation. We find that TM1 is also downregulated in human neuroblastoma cell lines, correlating with increasing malignancy. However, exogenous TM1 does not restore actin cytoskeleton organisation in neuroblastoma cells.
原肌球蛋白1（TM1）在多种转化细胞类型中表达下调，外源性表达TM1可恢复肌动蛋白组织并逆转细胞转化。我们发现TM1在人神经母细胞瘤细胞系中也表达下调，这与恶性程度增加相关。然而，外源性TM1并不能恢复神经母细胞瘤细胞中的肌动蛋白细胞骨架组织。
Zotero 插件