Boston Biomedical Research Institute, Watertown, MA, USA.
Int Rev Cell Mol Biol. 2010;281:91-128. doi: 10.1016/S1937-6448(10)81003-2.
The actin cytoskeleton is regulated by a variety of actin-binding proteins including those constituting the tropomyosin family. Tropomyosins are coiled-coil dimers that bind along the length of actin filaments. In muscles, tropomyosin regulates the interaction of actin-containing thin filaments with myosin-containing thick filaments to allow contraction. In nonmuscle cells where multiple tropomyosin isoforms are expressed, tropomyosins participate in a number of cellular events involving the cytoskeleton. This chapter reviews the current state of the literature regarding tropomyosin structure and function and discusses the evidence that tropomyosins play a role in regulating actin assembly.
肌动蛋白细胞骨架受各种肌动蛋白结合蛋白调节，包括构成原肌球蛋白家族的蛋白。原肌球蛋白是沿肌动蛋白丝长度结合的卷曲螺旋二聚体。在肌肉中，原肌球蛋白调节肌动蛋白含量的细丝与肌球蛋白含量的粗丝之间的相互作用，从而允许收缩。在表达多种原肌球蛋白同工型的非肌肉细胞中，原肌球蛋白参与涉及细胞骨架的许多细胞事件。本章综述了关于原肌球蛋白结构和功能的文献现状，并讨论了原肌球蛋白在调节肌动蛋白组装中发挥作用的证据。
