Granados-Soto Vinicio
Laboratorio de Farmacologia, Instituto de Investigaciones Quimico-Biologicas, Universidad Michoacana de San Nicolas de Hidalgo, Morelia, Michoacan, Mexico.
Drug News Perspect. 2003 Jun;16(5):299-307. doi: 10.1358/dnp.2003.16.5.829318.
Resveratrol, a phytoalexin found in red wine, has several pharmacological properties which include inhibition of arachidonate metabolism in leukocytes and platelets, modulation of lipid metabolism, inhibition of platelet aggregation and lipid peroxidation, reduction of expression and activity of cyclooxygenase-2. Resveratrol induces cell cycle arrest at S/G(2) phase transition and a pro-apoptotic cell death in several types of cancer cells. All these biological activities help to explain the vasorelaxing, anticancer and antiinflammatory activity of resveratrol. This article summarizes the wide range of biological activities of resveratrol in three disease states: cancer, coronary heart disease and pain. In addition, the mechanisms underlying these promising properties of resveratrol are also reviewed.
白藜芦醇是一种存在于红酒中的植物抗毒素，具有多种药理特性，包括抑制白细胞和血小板中的花生四烯酸代谢、调节脂质代谢、抑制血小板聚集和脂质过氧化、降低环氧合酶-2的表达和活性。白藜芦醇可诱导多种癌细胞在S/G(2)期转变时发生细胞周期停滞并导致促凋亡细胞死亡。所有这些生物学活性有助于解释白藜芦醇的血管舒张、抗癌和抗炎活性。本文总结了白藜芦醇在癌症、冠心病和疼痛这三种疾病状态下的广泛生物学活性。此外，还对白藜芦醇这些有前景特性的潜在机制进行了综述。
