活体肝移植后他克莫司相关迟发性后部白质脑病
Late onset of tacrolimus-related posterior leukoencephalopathy after living donor liver transplantation.
作者信息
Frühauf Nils R, Koeppen Dagger Susanne, Saner Fuat H, Egelhof Dagger Thomas, Stavrou Gregor, Nadalin Silvio, Broelsch Christoph E
机构信息
Department of General- and Transplant Surgery, University of Essen, Germany.
出版信息
Liver Transpl. 2003 Sep;9(9):983-5. doi: 10.1053/jlts.2003.50181.
Neurotoxicity is a well-known side effect of tacrolimus-based immunosuppression after liver transplantation. Until now, only 31 cases of immunosuppression-associated leukoencephalopathy in liver transplant recipients reported in the literature are related to tacrolimus therapy. We report a patient who developed a posterior leukoencephalopathy syndrome, secondary to tacrolimus-based immunosuppression, after living donor liver transplantation. The special features of this case are the sudden and late onset of neurologic symptoms, a persistent comatose state, and increased signal intensity in follow-up MRI.
神经毒性是肝移植后基于他克莫司的免疫抑制的一种众所周知的副作用。到目前为止，文献中报道的肝移植受者中仅有31例免疫抑制相关的白质脑病与他克莫司治疗有关。我们报告了1例活体供肝肝移植后发生继发于基于他克莫司的免疫抑制的后部白质脑病综合征的患者。该病例的特殊之处在于神经症状突发且出现较晚、持续昏迷状态以及随访磁共振成像（MRI）信号强度增加。
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