[俄罗斯俄罗斯族人群中烟酰胺腺嘌呤二核苷酸脱氢酶复合物（ND6）亚基6基因的多态性]

[Polymorphism of the gene for subunit 6 of the NADh dehydrogenase complex (ND6) in ethnic russian population in Russia].

作者信息

Kornienko I V, Vodolazhskiĭ D I, Mikhalkovich L S, Pavlichenko G N, Ivanov P L

机构信息

Central Laboratory of Medical and Forensic Identification, Ministry of Defense of the Russian Federation, Rostov-on-Don, 344010 Russia.

出版信息

Mol Biol (Mosk). 2003 Jul-Aug;37(4):595-600.

PMID:12942631

Abstract

A sample of ethnic Russians of Russia was tested for polymorphism of the NADH dehydrogenase subunit 6 (ND6) gene mapping to the mtDNA region 14,170-14,569. Genetic diversity of ND6 haplotypes was estimated at 0.406, and probability of haplotype random match, at 0.598. Combined with typing the mtDNA control region, analysis of the ND6 gene polymorphism was assumed to improve the reliability of forensic identification. Several point substitutions in the ND6 gene region proved to be associated with particular transitions in the mtDNA control region; the association was characterized with the phi coefficient.

摘要

对俄罗斯的俄罗斯族样本进行了检测，以确定定位于线粒体DNA区域14170 - 14569的NADH脱氢酶亚基6（ND6）基因的多态性。ND6单倍型的遗传多样性估计为0.406，单倍型随机匹配概率为0.598。结合线粒体DNA控制区的分型，对ND6基因多态性的分析被认为可提高法医鉴定的可靠性。ND6基因区域的几个点突变被证明与线粒体DNA控制区的特定转变有关；这种关联用φ系数来表征。