Haghighat N, al-Hashimi I
Department of Periodontics, Baylor College of Dentistry, 3302 Gaston Avenue, Dallas, Texas 75246, USA.
Clin Exp Rheumatol. 2003 Jul-Aug;21(4):485-8.
Sjögren's syndrome (SS) is chronic salivary gland disorder characterized by a reduction in salivary and lacrimal secretion. Elevation in salivary lactoferrin has been reported in SS patients. Fluctuation in the iron binding capacity of lactoferrin has been associated with cellular damage.
The purpose of this study was to compare the levels of salivary lactoferrin, total iron, and iron binding capacity in Sjögren's syndrome (SS) patients and healthy controls.
SDS-PAGE was used to examine the presence of lactoferrin in 102 patients and 20 healthy controls. A colorimetric assay was used to examine the level of total salivary iron and iron binding capacity in patients and controls.
A higher number of SS patients exhibited elevated levels of lactoferrin as compared to controls (86% vs. 20%, respectively). No significant difference was observed in the mean level of total iron in the saliva between patients and controls (12.6 micrograms/100 ml vs. 11.1 micrograms/100 ml, respectively). However, the total iron binding capacity of lactoferrin was significantly lower among SS patients than healthy controls (38.2 micrograms/100 ml vs. 61.8 micrograms/100 ml, respectively), p = 0.019.
The overall results of this study suggest a possible impairment of the iron binding capacity of saliva in SS patients. Such impairment may contribute to the cellular damage of the salivary glands observed in SS patients.
干燥综合征（SS）是一种慢性唾液腺疾病，其特征是唾液和泪液分泌减少。据报道，SS患者唾液乳铁蛋白水平升高。乳铁蛋白的铁结合能力波动与细胞损伤有关。
本研究的目的是比较干燥综合征（SS）患者和健康对照者唾液乳铁蛋白、总铁和铁结合能力的水平。
采用SDS-PAGE检测102例患者和20例健康对照者中乳铁蛋白的存在情况。采用比色法检测患者和对照者唾液总铁水平和铁结合能力。
与对照组相比，SS患者中乳铁蛋白水平升高的人数更多（分别为86%和20%）。患者和对照组唾液中总铁的平均水平未观察到显著差异（分别为12.6微克/100毫升和11.1微克/100毫升）。然而，SS患者中乳铁蛋白的总铁结合能力显著低于健康对照者（分别为38.2微克/100毫升和61.8微克/100毫升），p = 0.019。
本研究的总体结果表明，SS患者唾液的铁结合能力可能受损。这种损害可能导致SS患者唾液腺的细胞损伤。
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