Markusse H M, Otten H G, Vroom T M, Smeets T J, Fokkens N, Breedveld F C
Department of Rheumatology, Dr. Daniël Den Hoed Clinic, Rotterdam, The Netherlands.
Clin Rheumatol. 1992 Dec;11(4):521-5. doi: 10.1007/BF02283111.
In search of a simple non-invasive diagnostic test for primary Sjögren's syndrome (SS) the concentration of beta 2-microglobulin (beta 2-m), lysozyme (LZM) and lactoferrin (Lf) was measured in stimulated parotid saliva of 39 patients with primary SS, 42 patients suspected of the syndrome in whom the diagnosis could be excluded (NON-SS) and in 41 normal control individuals. Salivary fluid levels of beta 2-m, LZM and Lf exceeding the mean + 2 x standard deviation of healthy control values were found in respectively 58%, 23%, and 26% of the primary SS patients and in 7%, 11% and 0% of the NON-SS patients. The results of this study indicate that due to the low sensitivity the tests are not suitable as a screening procedure for patients suspected of having primary SS. However, measurement of beta 2-m in stimulated parotid saliva may be used as an adjunctive diagnostic test for primary SS.
为寻找一种用于原发性干燥综合征（SS）的简单非侵入性诊断试验，对39例原发性SS患者、42例疑似该综合征但诊断可排除的患者（非SS）以及41名正常对照个体的腮腺刺激唾液中β2-微球蛋白（β2-m）、溶菌酶（LZM）和乳铁蛋白（Lf）的浓度进行了测定。原发性SS患者中，β2-m、LZM和Lf的唾液水平超过健康对照值均值+2倍标准差的分别占58%、23%和26%，非SS患者中这一比例分别为7%、11%和0%。本研究结果表明，由于敏感性较低，这些试验不适合作为疑似原发性SS患者的筛查程序。然而，测定腮腺刺激唾液中的β2-m可作为原发性SS的辅助诊断试验。
