Department of Chemistry and Biochemistry, University of California-Los Angeles, Los Angeles, CA, USA.
J Dent Res. 2010 Oct;89(10):1016-23. doi: 10.1177/0022034510380414. Epub 2010 Aug 25.
The protein compositions, or the proteomes, found in human salivary and plasma fluids are compared. From recent experimental work by many laboratories, a catalogue of 2290 proteins found in whole saliva has been compiled. This list of salivary proteins is compared with the 2698 proteins found in plasma. Approximately 27% of the whole-saliva proteins are found in plasma. However, despite this apparent low degree of overlap, the distribution found across Gene Ontological categories, such as molecular function, biological processes, and cellular components, shows significant similarities. Moreover, nearly 40% of the proteins that have been suggested to be candidate markers for diseases such as cancer, cardiovascular disease, and stroke can be found in whole saliva. These comparisons and correlations should encourage researchers to consider the use of saliva to discover new protein markers of disease and as a diagnostic non-proximal fluid to detect early signs of disease throughout the body.
比较了人类唾液和血浆中发现的蛋白质组成，或蛋白质组。通过许多实验室的最新实验工作，已经编制了一份在全唾液中发现的 2290 种蛋白质的目录。将这份唾液蛋白清单与在血浆中发现的 2698 种蛋白质进行比较。大约 27%的全唾液蛋白存在于血浆中。然而，尽管这种明显的重叠程度较低，但在基因本体论类别（如分子功能、生物过程和细胞成分）中的分布显示出显著的相似性。此外，近 40%的被认为是癌症、心血管疾病和中风等疾病候选标志物的蛋白质可以在全唾液中找到。这些比较和相关性应该鼓励研究人员考虑使用唾液来发现疾病的新蛋白质标志物，并将其作为一种非近端诊断液，以检测全身早期疾病迹象。
