Voormolen M H, Lohle P N, Fransen H, Juttmann J R, de Waal Malefijt J, Lampmann L E
Sint Elisabeth Ziekenhuis, Postbus 90.151, 5000 LC Tilburg.
Ned Tijdschr Geneeskd. 2003 Aug 9;147(32):1549-53.
To describe the technique of percutaneous vertebroplasty and the short-term results in patients with symptomatic, osteoporotic vertebral compression fractures.
Prospective follow-up study.
In a pilot-study to evaluate the short-term safety and effectiveness of percutaneous vertebroplasty, 18 consecutive patients with a total of 33 osteoporotic thoracic or lumbar vertebral compression fractures were treated from October 2001 to June 2002 with a follow-up of 3-6 months. The indication for treatment was a symptomatic, therapy-resistant osteoporotic vertebral compression fracture. Percutaneous vertebroplasty was performed under radiographic control, after previous intraossal venography, using bone cement mixed with barium sulphate. Post-procedural follow-up consisted of radiological evaluation with conventional thoracolumbar X-rays and MRI scans, and interviews of the patients.
Percutaneous vertebroplasty was technically successful in 31 of 33 vertebral fractures (94%), and in 16 of 18 patients (89%). One patient with extreme venous contrast leakage could not be treated. Sixteen patients had less or no pain after treatment. One patient retained thoracolumbar back pain after inadequate cementations and refused further treatment. None of the patients reported aggravation of symptoms following the procedure. Contrast leakage was absent in 18 vertebrae. In 8 vertebrae there was contrast leakage to paravertebral veins. In three of these cases the leakage was so severe that embolisation was performed, with success in one case. In 13 vertebrae, cement leakage to intervertebral and paravertebral spaces and pedicular cement spurs were seen, without clinical consequences. Immediately after the procedure and during follow-up there were no clinically relevant complications.
Percutaneous vertebroplasty was a technically feasible treatment in these patients with symptomatic, therapy-resistant, osteoporotic vertebral fractures. The first short-term results were comparable with results in the literature. A prospective randomised intervention study will be needed to compare percutaneous vertebroplasty with optimal conservative treatment.
描述经皮椎体成形术技术以及有症状的骨质疏松性椎体压缩骨折患者的短期治疗结果。
前瞻性随访研究。
在一项评估经皮椎体成形术短期安全性和有效性的初步研究中,2001年10月至2002年6月连续治疗了18例患者,共33处骨质疏松性胸腰椎椎体压缩骨折,随访3至6个月。治疗指征为有症状的、对治疗抵抗的骨质疏松性椎体压缩骨折。在先前进行骨内静脉造影后,于放射学监测下,使用混合硫酸钡的骨水泥实施经皮椎体成形术。术后随访包括采用传统胸腰椎X线和MRI扫描进行放射学评估以及对患者进行访谈。
33处椎体骨折中的31处(94%)以及18例患者中的16例(89%)经皮椎体成形术在技术上成功。1例静脉造影剂严重渗漏的患者无法接受治疗。16例患者治疗后疼痛减轻或消失。1例患者在骨水泥注入不充分后仍有胸腰椎背痛,拒绝进一步治疗。无患者报告术后症状加重。18个椎体未见造影剂渗漏。8个椎体造影剂渗漏至椎旁静脉。其中3例渗漏严重,实施了栓塞,1例成功。13个椎体可见骨水泥渗漏至椎间隙和椎旁间隙以及椎弓根骨水泥骨突,无临床后果。术后即刻及随访期间无临床相关并发症。
经皮椎体成形术对于这些有症状的、对治疗抵抗的骨质疏松性椎体骨折患者在技术上是可行的治疗方法。首批短期治疗结果与文献报道结果相当。需要进行一项前瞻性随机干预研究以比较经皮椎体成形术与最佳保守治疗。