苯并呋喃对映体衍生物的合成及其对非小细胞支气管肺癌细胞系（NSCLC-N6）的细胞毒性活性
Synthesis and cytotoxic activity against a non-small-cell bronchopulmonary carcinoma line (NSCLC-N6) of benzofuran enantiomeric derivatives.
作者信息
Hélesbeux J J, Duval O, Séraphin D, Roussakis C, Richomme P
机构信息
Laboratoire SONAS, UFR des Sciences Pharmaceutiques et Ingénierie de la Santé, 16, Bd Daviers, 49100 Angers, France.
出版信息
J Enzyme Inhib Med Chem. 2003 Apr;18(2):159-65. doi: 10.1080/1475636032000069828.
PMID:12943200
Abstract
The synthesis of 2-isopropenyl-2,3-dihydrobenzofuranic enantioisomers is described. Ortho-(2-hydroxy-3-methyl-but-3-enyl)phenol synthons are used as precursors to these structures. In vitro antitumor activity against a non-small-cell bronchopulmonary carcinoma line (NSCLC-N6) of these enantioisomers has been investigated.
摘要
描述了2-异丙烯基-2,3-二氢苯并呋喃对映异构体的合成。邻-(2-羟基-3-甲基-丁-3-烯基)苯酚合成子被用作这些结构的前体。已经研究了这些对映异构体对非小细胞支气管肺癌细胞系(NSCLC-N6)的体外抗肿瘤活性。
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