el Kihel L, Bosch S, Dherbomez M, Roussakis C, Letourneux Y
Laboratoire de Synthèse et Etude de Substances Naturelles à Activité's Biologiques, Université de La Rochelle, France.
Anticancer Res. 1999 Mar-Apr;19(2A):1229-34.
Various new aminosterols were synthesized. The antiproliferative activity of these compounds (I-IV) was studied in vitro on a continuous human non small-cell bronchopulmonary carcinoma line (NSCLC-N6) at the cell cycle level. The histograms indicate cell blockage in Phase Gl (compound I-III) associated with a reduction in the number of cells phases S and G2M and appearance of cellular debris derived from cells in Phase G1.
合成了多种新型氨基甾醇。在细胞周期水平上，对这些化合物（I-IV）在人非小细胞支气管肺癌连续细胞系（NSCLC-N6）上进行了体外抗增殖活性研究。直方图表明，G1期（化合物I-III）细胞阻滞，同时S期和G2M期细胞数量减少，且出现了源自G1期细胞的细胞碎片。
