MacKinnon Dean F, Zandi Peter P, Gershon Elliot S, Nurnberger John I, DePaulo J Raymond
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of medicine, Meyer 3-181, 600 N. Wolfe Street, Baltimore, MD 21287, USA.
Am J Psychiatry. 2003 Sep;160(9):1696-8. doi: 10.1176/appi.ajp.160.9.1696.
Comorbid bipolar and panic disorders aggregate in families. A phenotypic trait shared by both disorders is the sudden shift in affect observed in panic attacks and some rapid cycling states. The authors investigated whether comorbidity of bipolar disorder and panic disorder is associated with rapid mood switching in families with a high rate of bipolar disorder.
Six hundred six subjects with bipolar disorder from the NIMH Bipolar Disorder Genetics Initiative were included in the study. Logistic regression analysis was used to analyze rapid mood switching as a function of panic disorder diagnosis, sex, and familial risk for panic.
Familial panic and the diagnosis of panic disorder in an individual subject increased the odds for rapid mood switching. The familial effect persisted when individuals with panic disorder were excluded from the analysis.
Panic and rapid mood switching occurring together in familial bipolar disorder may define a useful subphenotype for future studies.
双相情感障碍与惊恐障碍的共病在家族中聚集。这两种疾病共有的一个表型特征是在惊恐发作和某些快速循环状态中观察到的情感突然转变。作者调查了双相情感障碍与惊恐障碍的共病是否与双相情感障碍发病率高的家族中的快速情绪转换有关。
来自美国国立精神卫生研究所双相情感障碍遗传学倡议的606名双相情感障碍患者被纳入研究。使用逻辑回归分析来分析快速情绪转换作为惊恐障碍诊断、性别和惊恐家族风险的函数。
家族性惊恐以及个体受试者的惊恐障碍诊断增加了快速情绪转换的几率。当将患有惊恐障碍的个体排除在分析之外时，家族效应仍然存在。
家族性双相情感障碍中同时出现的惊恐和快速情绪转换可能为未来的研究定义一个有用的亚表型。
