MacKinnon D F, Xu J, McMahon F J, Simpson S G, Stine O C, McInnis M G, DePaulo J R
Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Am J Psychiatry. 1998 Jun;155(6):829-31. doi: 10.1176/ajp.155.6.829.
The authors performed an analysis of their published chromosome 18 linkage data on 28 families in which there was bipolar disorder to test the potential of comorbid panic disorder to define a genetic subtype of bipolar disorder.
Families ascertained through probands with bipolar I disorder were stratified into three groups based on a history of panic disorder, panic attacks, or no panic attacks in the probands. Multipoint nonparametric linkage analysis was performed on data from bipolar I and II family members in each group.
Linkage scores for five consecutive 18q marker loci were highest in the families of the probands with panic disorder and lowest for the families of the probands without panic attacks.
This study supports the authors' previously reported clinical hypothesis of a genetic subtype of bipolar disorder identified by comorbid panic disorder. The hypothesis merits prospective testing.
作者对他们发表的28个双相情感障碍家族的18号染色体连锁数据进行分析，以测试共病惊恐障碍是否有可能定义双相情感障碍的一个遗传亚型。
通过I型双相情感障碍先证者确定的家族，根据先证者有无惊恐障碍病史、惊恐发作史或无惊恐发作，分为三组。对每组中I型和II型双相情感障碍家族成员的数据进行多点非参数连锁分析。
在有惊恐障碍的先证者家族中，连续5个18q标记位点的连锁分数最高，而在无惊恐发作的先证者家族中最低。
本研究支持作者先前报道的临床假设，即共病惊恐障碍可确定双相情感障碍的一个遗传亚型。该假设值得进行前瞻性检验。
